Bisphosphonates: Mechanisms of Action

I. Introduction II. Chemistry III. Effects in Vivo A. Inhibition of calcification B. Inhibition of bone resorption C. Effects on bone formation D. Effects on noncalcified tissues IV. Mechanisms of Action A. Calcification B. Bone resorption C. Other effects V. Pharmacokinetics VI. Animal Toxicology a...

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Bibliographic Details
Published in:Endocrine reviews 1998-02, Vol.19 (1), p.80-100
Main Author: Fleisch, Herbert
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Bisphosphonates
Bone Development - drug effects
Bone Resorption - physiopathology
Bones, joints and connective tissue. Antiinflammatory agents
Diphosphonates - chemistry
Diphosphonates - metabolism
Diphosphonates - pharmacology
Humans
Medical sciences
Pharmacology. Drug treatments
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Summary:I. Introduction II. Chemistry III. Effects in Vivo A. Inhibition of calcification B. Inhibition of bone resorption C. Effects on bone formation D. Effects on noncalcified tissues IV. Mechanisms of Action A. Calcification B. Bone resorption C. Other effects V. Pharmacokinetics VI. Animal Toxicology and Human Adverse Events A. Animal toxicology B. Human adverse events VII. Conclusion
ISSN:0163-769X
1945-7189
DOI:10.1210/edrv.19.1.0325