APC resistance in an elite female athlete

In a routine checkup the family history of an elite female mogul skier was found to contain an unusually high number of thrombotic incidents. This prompted us to do diagnostic thrombophilia studies, which revealed a resistance to activated protein C, a heterozygous factor V Leiden disorder. This is...

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Bibliographic Details
Published in:Medicine and science in sports and exercise 1998-02, Vol.30 (2), p.183-184
Main Authors: HILBERG, T, MOESSMER, G, HARTARD, M, JESCHKE, D
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Exercise Therapy
Factor V - genetics
Female
Hematologic and hematopoietic diseases
Heparin, Low-Molecular-Weight - therapeutic use
Heterozygote
Humans
Medical sciences
Platelet diseases and coagulopathies
Point Mutation
Protein C - physiology
Skiing
Space life sciences
Thrombophilia - genetics
Thrombophilia - prevention & control
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Summary:In a routine checkup the family history of an elite female mogul skier was found to contain an unusually high number of thrombotic incidents. This prompted us to do diagnostic thrombophilia studies, which revealed a resistance to activated protein C, a heterozygous factor V Leiden disorder. This is the first documented case of APC resistance in an elite female athlete. Since high performance sports are known to carry an increased risk of thrombogenesis, measures to avoid thrombosis or a thromboembolic event must be initiated in case of known APC resistance. Suitable measures are early anticoagulation during periods of immobilization, a single dose of low molecular weight heparin, leg muscle exercises for long distance flights, and avoidance of hemoconcentration with a sufficient oral fluid intake.
ISSN:0195-9131
1530-0315
DOI:10.1097/00005768-199802000-00001