Hypochondroplastic dwarfism in the Irish setter

Two test matings in the Irish setter were performed, and genetic, clinical, morphometric, radiographic, bone histological and plasma and urine biochemical features of dwarfism were studied. All offspring were phenotypically normal at birth and weaning, but at the age of 2–5 to 4 months the longitudi...

Full description

Saved in:
Bibliographic Details
Published in:Journal of small animal practice 1998, Vol.39 (1), p.10-14
Main Authors: Hanssen, I, Falck, G, Grammeltvedt, A.T, Haug, E, Isaksen, C.V
Format: Article
Language:English
Subjects:
Achondroplasia - diagnostic imaging
Achondroplasia - genetics
Achondroplasia - veterinary
Amino Acids - urine
Animals
Biomarkers - blood
Biomarkers - urine
blood plasma
body measurements
bone formation
Bones of Upper Extremity - diagnostic imaging
Bones of Upper Extremity - pathology
Cartilage - pathology
Cohort Studies
Collagen - blood
Collagen Type I
diagnostic techniques
dogs
Dogs - abnormalities
Dogs - physiology
dwarfing
Dwarfism - diagnostic imaging
Dwarfism - genetics
Dwarfism - veterinary
Female
inheritance (genetics)
Insulin-Like Growth Factor I - analysis
Irish Setter
Male
Osteocalcin - blood
Peptides - blood
Radiography
recessive genes
urine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two test matings in the Irish setter were performed, and genetic, clinical, morphometric, radiographic, bone histological and plasma and urine biochemical features of dwarfism were studied. All offspring were phenotypically normal at birth and weaning, but at the age of 2–5 to 4 months the longitudinal growth of the spine and leg bones was retarded in the dwarfs compared with the normal littermates. Most dwarfs performed well, even in the field. Radiographic and histological evaluations revealed a hypochondroplasia. A morphometric diagnostic method for Irish setter dwarfism was developed. A single autosomal recessive mode of inheritance was verified.
ISSN:0022-4510
1748-5827
DOI:10.1111/j.1748-5827.1998.tb03662.x