Long-term effects of consuming foods containing psyllium seed husk on serum lipids in subjects with hypercholesterolemia

The effects of consuming foods containing 0 (control), 3.4, 6.8, or 10.2 g psyllium seed husk (PSH)/d for 24 wk on the serum lipid profile were assessed in this randomized, double-blind controlled study. Men and women (n = 286) with LDL-cholesterol concentrations between 3.36 and 5.68 mmol/L (130 an...

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Bibliographic Details
Published in:The American journal of clinical nutrition 1998-03, Vol.67 (3), p.367-376
Main Authors: Davidson, MH, Maki, KC, Kong, JC, Dugan, LD, Torri, SA, Hall, HA, Drennan, KB, Anderson, SM, Fulgoni, VL, Saldanha, LG, Olson, BH
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
BLOOD LIPIDS
BLOOD SERUM
CHOLESTEROL
Cholesterol, HDL - blood
Cholesterol, LDL - blood
DIET
Diet Records
DIET TREATMENT
Dietary fiber
Dietary Fiber - administration & dosage
Dietary Fiber - adverse effects
Dietary Fiber - therapeutic use
DIETARY FIBRES
Disorders of blood lipids. Hyperlipoproteinemia
DOSAGE EFFECTS
Double-Blind Method
ENERGY INTAKE
EXPERIMENTATION
Female
HIGH DENSITY LIPOPROTEIN
HUMAN NUTRITION
Humans
Hypercholesterolemia - blood
Hypercholesterolemia - diet therapy
HYPERLIPIDAEMIA
Lipids
LIPOPROTEINS
LONGITUDINAL STUDIES
LOW DENSITY LIPOPROTEIN
Male
Medical sciences
MEN
Metabolic diseases
Middle Aged
MUCILAGES
NATIONAL CHOLESTEROL EDUCATION PROGRAM
NUTRIENT INTAKE
Nutrition
PATIENT COMPLIANCE
Psyllium - administration & dosage
Psyllium - adverse effects
Psyllium - therapeutic use
SEEDS
SUPPLEMENTS
TRIGLYCERIDES
Triglycerides - blood
WOMEN
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Summary:The effects of consuming foods containing 0 (control), 3.4, 6.8, or 10.2 g psyllium seed husk (PSH)/d for 24 wk on the serum lipid profile were assessed in this randomized, double-blind controlled study. Men and women (n = 286) with LDL-cholesterol concentrations between 3.36 and 5.68 mmol/L (130 and 220 mg/dL) were randomly assigned to one of four treatment groups after following a low-fat diet for > or = 8 wk. At week 24, LDL cholesterol was 3% above baseline in the control group. In the group consuming 10.2 g PSH/d, LDL cholesterol remained below baseline during treatment, with a value 5.3% below that of the control group at week 24 (P < 0.05 compared with the control group). No significant differences were observed in HDL cholesterol or triacylglycerol. Although modest, the effect of 10.2 g PSH/d on LDL cholesterol (relative to the control) persisted throughout the 24-wk treatment period, indicating potential for long-term benefit.
ISSN:0002-9165
1938-3207
DOI:10.1093/ajcn/67.3.367