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Blood-nerve barrier in IgM paraproteinemic neuropathy : a clinicopathologic assessment
We report the pathologic findings in a patient with sensorimotor neuropathy associated with Waldenström's macroglobulinemia, particularly in relation to blood-nerve barrier defects. The monoclonal IgM was of kappa type and possessed anti-HNK-1 activity. A sural nerve biopsy specimen revealed se...
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| Published in: | Acta neuropathologica 1998-02, Vol.95 (2), p.184-192 |
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| Main Authors: | , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c411t-ed08805ce31e214db19ba9e4215a5cd082c68ae4ce6b195c252a4532e522af333 |
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| container_end_page | 192 |
| container_issue | 2 |
| container_start_page | 184 |
| container_title | Acta neuropathologica |
| container_volume | 95 |
| creator | KANDA, T USUI, S BEPPU, H MIYAMOTO, K YAMAWAKI, M ODA, M |
| description | We report the pathologic findings in a patient with sensorimotor neuropathy associated with Waldenström's macroglobulinemia, particularly in relation to blood-nerve barrier defects. The monoclonal IgM was of kappa type and possessed anti-HNK-1 activity. A sural nerve biopsy specimen revealed severe loss of myelinated and unmyelinated nerve fibers and gaps between adjacent endothelial cells of small endoneurial vessels. Postmortem findings 3 years later included severe loss of myelinated nerve fibers and diffuse infiltration by lymphoplasmacytic B cells throughout the peripheral nervous system, sparing the central nervous system. Findings in this case suggest an immune attack against endoneurial endothelial cells with permeation of IgM into peripheral nerve tissue. |
| doi_str_mv | 10.1007/s004010050785 |
| format | article |
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The monoclonal IgM was of kappa type and possessed anti-HNK-1 activity. A sural nerve biopsy specimen revealed severe loss of myelinated and unmyelinated nerve fibers and gaps between adjacent endothelial cells of small endoneurial vessels. Postmortem findings 3 years later included severe loss of myelinated nerve fibers and diffuse infiltration by lymphoplasmacytic B cells throughout the peripheral nervous system, sparing the central nervous system. Findings in this case suggest an immune attack against endoneurial endothelial cells with permeation of IgM into peripheral nerve tissue.</description><identifier>ISSN: 0001-6322</identifier><identifier>EISSN: 1432-0533</identifier><identifier>DOI: 10.1007/s004010050785</identifier><identifier>PMID: 9498055</identifier><identifier>CODEN: ANPTAL</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Aged ; Autopsy ; Biological and medical sciences ; Biopsy ; Central nervous system ; Endothelial cells ; Endothelium, Vascular - pathology ; Endothelium, Vascular - ultrastructure ; Female ; Fibers ; Hematologic and hematopoietic diseases ; Humans ; Immunoglobulin M ; Immunoglobulin M - blood ; Immunoglobulin M - cerebrospinal fluid ; Intercellular Junctions - pathology ; Intercellular Junctions - ultrastructure ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphocytes B ; Macroglobulinemia ; Male ; Medical sciences ; Microscopy, Electron ; Middle Aged ; Nerve Fibers - pathology ; Nerve Fibers - ultrastructure ; Nervous system ; Peripheral nerves ; Peripheral neuropathy ; Reference Values ; Sensorimotor system ; Spinal Cord - pathology ; Spinal Nerve Roots - pathology ; Sural nerve ; Sural Nerve - blood supply ; Sural Nerve - pathology ; Sural Nerve - ultrastructure ; Waldenstrom Macroglobulinemia - immunology ; Waldenstrom Macroglobulinemia - pathology</subject><ispartof>Acta neuropathologica, 1998-02, Vol.95 (2), p.184-192</ispartof><rights>1998 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 1998.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-ed08805ce31e214db19ba9e4215a5cd082c68ae4ce6b195c252a4532e522af333</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2116154$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9498055$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KANDA, T</creatorcontrib><creatorcontrib>USUI, S</creatorcontrib><creatorcontrib>BEPPU, H</creatorcontrib><creatorcontrib>MIYAMOTO, K</creatorcontrib><creatorcontrib>YAMAWAKI, M</creatorcontrib><creatorcontrib>ODA, M</creatorcontrib><title>Blood-nerve barrier in IgM paraproteinemic neuropathy : a clinicopathologic assessment</title><title>Acta neuropathologica</title><addtitle>Acta Neuropathol</addtitle><description>We report the pathologic findings in a patient with sensorimotor neuropathy associated with Waldenström's macroglobulinemia, particularly in relation to blood-nerve barrier defects. The monoclonal IgM was of kappa type and possessed anti-HNK-1 activity. A sural nerve biopsy specimen revealed severe loss of myelinated and unmyelinated nerve fibers and gaps between adjacent endothelial cells of small endoneurial vessels. Postmortem findings 3 years later included severe loss of myelinated nerve fibers and diffuse infiltration by lymphoplasmacytic B cells throughout the peripheral nervous system, sparing the central nervous system. 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Myelofibrosis</subject><subject>Lymphocytes B</subject><subject>Macroglobulinemia</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Middle Aged</subject><subject>Nerve Fibers - pathology</subject><subject>Nerve Fibers - ultrastructure</subject><subject>Nervous system</subject><subject>Peripheral nerves</subject><subject>Peripheral neuropathy</subject><subject>Reference Values</subject><subject>Sensorimotor system</subject><subject>Spinal Cord - pathology</subject><subject>Spinal Nerve Roots - pathology</subject><subject>Sural nerve</subject><subject>Sural Nerve - blood supply</subject><subject>Sural Nerve - pathology</subject><subject>Sural Nerve - ultrastructure</subject><subject>Waldenstrom Macroglobulinemia - immunology</subject><subject>Waldenstrom Macroglobulinemia - pathology</subject><issn>0001-6322</issn><issn>1432-0533</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNpdkEtLAzEUhYMotVaXLoUBxd1ocpPMdNxp8QWKG3U73Ka3mjKT1GRG6L83aino6j7Ox-FwGDsU_ExwXp5HzhVPm-blWG-xoVAScq6l3GZDzrnICwmwy_ZiXKQLSqUHbFCpasy1HrLXq8b7We4ofFI2xRAshcy67P7tMVtiwGXwHVlHrTWZoz74JXbvq-wiw8w01lnz8_CNf0sAxkgxtuS6fbYzxybSwXqO2MvN9fPkLn94ur2fXD7kRgnR5TTj45TDkBQEQs2moppiRQqERm2SCKYYIylDRZK0AQ2otATSADiXUo7Y6a9vyvnRU-zq1kZDTYOOfB_rsipBclEk8PgfuPB9cClbDUroAlShIVH5L2WCjzHQvF4G22JY1YLX323Xf9pO_NHatZ-2NNvQ63qTfrLWMRps5gGdsXGDgRCF0Ep-AbZThdU</recordid><startdate>19980201</startdate><enddate>19980201</enddate><creator>KANDA, T</creator><creator>USUI, S</creator><creator>BEPPU, H</creator><creator>MIYAMOTO, K</creator><creator>YAMAWAKI, M</creator><creator>ODA, M</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19980201</creationdate><title>Blood-nerve barrier in IgM paraproteinemic neuropathy : a clinicopathologic assessment</title><author>KANDA, T ; USUI, S ; BEPPU, H ; MIYAMOTO, K ; YAMAWAKI, M ; ODA, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-ed08805ce31e214db19ba9e4215a5cd082c68ae4ce6b195c252a4532e522af333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Aged</topic><topic>Autopsy</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Central nervous system</topic><topic>Endothelial cells</topic><topic>Endothelium, Vascular - pathology</topic><topic>Endothelium, Vascular - ultrastructure</topic><topic>Female</topic><topic>Fibers</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunoglobulin M</topic><topic>Immunoglobulin M - blood</topic><topic>Immunoglobulin M - cerebrospinal fluid</topic><topic>Intercellular Junctions - pathology</topic><topic>Intercellular Junctions - ultrastructure</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphocytes B</topic><topic>Macroglobulinemia</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Middle Aged</topic><topic>Nerve Fibers - pathology</topic><topic>Nerve Fibers - ultrastructure</topic><topic>Nervous system</topic><topic>Peripheral nerves</topic><topic>Peripheral neuropathy</topic><topic>Reference Values</topic><topic>Sensorimotor system</topic><topic>Spinal Cord - pathology</topic><topic>Spinal Nerve Roots - pathology</topic><topic>Sural nerve</topic><topic>Sural Nerve - blood supply</topic><topic>Sural Nerve - pathology</topic><topic>Sural Nerve - ultrastructure</topic><topic>Waldenstrom Macroglobulinemia - immunology</topic><topic>Waldenstrom Macroglobulinemia - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KANDA, T</creatorcontrib><creatorcontrib>USUI, S</creatorcontrib><creatorcontrib>BEPPU, H</creatorcontrib><creatorcontrib>MIYAMOTO, K</creatorcontrib><creatorcontrib>YAMAWAKI, M</creatorcontrib><creatorcontrib>ODA, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neuropathologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KANDA, T</au><au>USUI, S</au><au>BEPPU, H</au><au>MIYAMOTO, K</au><au>YAMAWAKI, M</au><au>ODA, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood-nerve barrier in IgM paraproteinemic neuropathy : a clinicopathologic assessment</atitle><jtitle>Acta neuropathologica</jtitle><addtitle>Acta Neuropathol</addtitle><date>1998-02-01</date><risdate>1998</risdate><volume>95</volume><issue>2</issue><spage>184</spage><epage>192</epage><pages>184-192</pages><issn>0001-6322</issn><eissn>1432-0533</eissn><coden>ANPTAL</coden><abstract>We report the pathologic findings in a patient with sensorimotor neuropathy associated with Waldenström's macroglobulinemia, particularly in relation to blood-nerve barrier defects. The monoclonal IgM was of kappa type and possessed anti-HNK-1 activity. A sural nerve biopsy specimen revealed severe loss of myelinated and unmyelinated nerve fibers and gaps between adjacent endothelial cells of small endoneurial vessels. Postmortem findings 3 years later included severe loss of myelinated nerve fibers and diffuse infiltration by lymphoplasmacytic B cells throughout the peripheral nervous system, sparing the central nervous system. Findings in this case suggest an immune attack against endoneurial endothelial cells with permeation of IgM into peripheral nerve tissue.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>9498055</pmid><doi>10.1007/s004010050785</doi><tpages>9</tpages></addata></record> |
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| ispartof | Acta neuropathologica, 1998-02, Vol.95 (2), p.184-192 |
| issn | 0001-6322 1432-0533 |
| language | eng |
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| source | Springer Nature |
| subjects | Aged Autopsy Biological and medical sciences Biopsy Central nervous system Endothelial cells Endothelium, Vascular - pathology Endothelium, Vascular - ultrastructure Female Fibers Hematologic and hematopoietic diseases Humans Immunoglobulin M Immunoglobulin M - blood Immunoglobulin M - cerebrospinal fluid Intercellular Junctions - pathology Intercellular Junctions - ultrastructure Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocytes B Macroglobulinemia Male Medical sciences Microscopy, Electron Middle Aged Nerve Fibers - pathology Nerve Fibers - ultrastructure Nervous system Peripheral nerves Peripheral neuropathy Reference Values Sensorimotor system Spinal Cord - pathology Spinal Nerve Roots - pathology Sural nerve Sural Nerve - blood supply Sural Nerve - pathology Sural Nerve - ultrastructure Waldenstrom Macroglobulinemia - immunology Waldenstrom Macroglobulinemia - pathology |
| title | Blood-nerve barrier in IgM paraproteinemic neuropathy : a clinicopathologic assessment |
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