Determinants of Human Immunodeficiency Virus DNA and RNA Shedding in the Anal-Rectal Canal of Homosexual Men

To define the determinants of anal-rectal shedding of human immunodeficiency virus (HIV) DNA and RNA, 374 HIV-seropositive homosexual men were tested. Factors independently associated with detection of anal-rectal HIV DNA included anal-rectal inflammation and detection of anal human papillomavirus D...

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Bibliographic Details
Published in:The Journal of infectious diseases 1998-03, Vol.177 (3), p.571-578
Main Authors: Kiviat, Nancy B., Critchlow, Cathy W., Hawes, Stephen E., Kuypers, Jane, Surawicz, Christina, Goldbaum, Gary, van Burik, Jo-Anne, Lampinen, Thomas, Holmes, King K.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
AIDS
AIDS/HIV
Anal Canal - pathology
Anal Canal - virology
Biological and medical sciences
Bisexuality
DNA
DNA, Viral - analysis
Fundamental and applied biological sciences. Psychology
HIV
HIV 1
HIV Seropositivity - virology
Homosexuality
Humans
Inflammation
Intestinal Mucosa - virology
Lymphocytes
Lymphoid tissue
Major Articles
Male
Microbiology
Middle Aged
Polymerase chain reaction
Prospective Studies
Rectum - pathology
Rectum - virology
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
RNA
RNA, Viral - analysis
RNA, Viral - blood
Simplexvirus
Virology
Virus Shedding
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Summary:To define the determinants of anal-rectal shedding of human immunodeficiency virus (HIV) DNA and RNA, 374 HIV-seropositive homosexual men were tested. Factors independently associated with detection of anal-rectal HIV DNA included anal-rectal inflammation and detection of anal human papillomavirus DNA; predictors of HIV RNA included detection of anal-rectal HIV DNA, anal-rectal inflammation, and high plasma HIV RNA levels. The latter (>10,000 copies/mL) was the main determinant of anal-rectal HIV RNA shedding when HIV DNA (e.g., HIV-infected cells) was not detected in the anal-rectal sample. The local presence of HIV-infected cells and local inflammation were the principal determinants of HIV RNA among those with low (
ISSN:0022-1899
1537-6613
DOI:10.1086/514239