The action of diltiazem and gallopamil (D600) on calcium channel current and charge movement in mouse Purkinje neurons

The dihydropyridines (DHP) receptor forms a high threshold L-type calcium channel in various excitable cells. In skeletal and cardiac muscle cells, a DHP receptor antagonist blocks not only the voltage-gated calcium current but also immobilizes the charge movement linked to the receptor. The DHP rec...

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Bibliographic Details
Published in:Neuroscience letters 1998-01, Vol.241 (2), p.163-166
Main Authors: Bournaud, R, Hidalgo, J, Melliti, K, Shimahara, T
Format: Article
Language:English
Subjects:
Animals
Benzothiazepines
Biological and medical sciences
Calcium channel
Calcium Channel Blockers - pharmacology
Central nervous system
Cerebellar Purkinje neurons
Dihydropyridines receptor
Diltiazem - pharmacology
Electrophysiology
Fundamental and applied biological sciences. Psychology
Gallopamil - pharmacology
Intramembrane charge movement
Ion Channel Gating
Membrane Potentials - drug effects
Mice
Patch-Clamp Techniques
Phenylalkylamines
Purkinje Cells - drug effects
Vertebrates: nervous system and sense organs
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Summary:The dihydropyridines (DHP) receptor forms a high threshold L-type calcium channel in various excitable cells. In skeletal and cardiac muscle cells, a DHP receptor antagonist blocks not only the voltage-gated calcium current but also immobilizes the charge movement linked to the receptor. The DHP receptor is also present in cerebellar Purkinje neurons. Previously, we showed that nifedipine immobilizes a part of the charge movement but has no effect on the calcium channel current recorded in freshly dissociated mice Purkinje neurons. We report here the effect of other families of DHP receptor antagonists, benzothiazepines and phenylalkylamines, on the physiological properties of this receptor in mouse Purkinje neurons.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(97)00970-1