OPTIC NEURITIS: VARIATIONS IN TEMPORAL MODULATION SENSITIVITY WITH RETINAL ECCENTRICITY

Temporal modulation sensitivity functions were measured centrally and at eccentricities of 2.5°, 5° and 10° in the temporal visual field of 12 patients with recovered optic neuritis and in a group of matched normal controls. A circular, spatially uniform stimulus of 1° angular subtense was presented...

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Bibliographic Details
Published in:Brain (London, England : 1878) England : 1878), 1990-04, Vol.113 (2), p.487-496
Main Authors: EDGAR, GRAHAM K., FOSTER, DAVID H., HONAN, WILLIAM P., HERON, JAMES R., SNELGAR, ROSEMARY S.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Diseases of visual field, optic nerve, optic chiasma and optic tracts
Female
Humans
Male
Medical sciences
Ophthalmology
Optic Neuritis - physiopathology
Photic Stimulation
Retina - physiopathology
Sensory Thresholds
Time Factors
Visual Fields
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Summary:Temporal modulation sensitivity functions were measured centrally and at eccentricities of 2.5°, 5° and 10° in the temporal visual field of 12 patients with recovered optic neuritis and in a group of matched normal controls. A circular, spatially uniform stimulus of 1° angular subtense was presented with sinusoidal modulation at 5, 8, 14 and 23 Hz. The general pattern of results in patients was a loss of sensitivity relative to normal controls at all temporal frequencies at 0° and 2.5° eccentricity, with rather greater losses occurring at the medium-to-lower temporal frequencies. At 5° eccentricity, the losses were confined to medium temporal frequencies only, and at 10° eccentricity there was no significant loss at any temporal frequency. These findings may be explained by a greater vulnerability of optic nerve fibres of small diameter to the effects of demyelinating disease.
ISSN:0006-8950
1460-2156
DOI:10.1093/brain/113.2.487