Predictors of Relapse and Rehospitalization in Schizophrenia and Schizoaffective Disorder

Abstract In a German multicenter treatment study, 354 patients with schizophrenia and schizoaffective disorder were followed for 2 years. The data collected were taken as a basis for the present predictor study. For the first time, the technique of classification and regression tree (CART) analysis...

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Bibliographic Details
Published in:Schizophrenia bulletin 1998, Vol.24 (1), p.87-98
Main Authors: Doering, Stephan, Müller, Elfriede, Köpcke, Wolfgang, Pietzcker, Adolf, Gaebel, Wolfgang, Linden, Michael, Müller, Peter, Müller-Spahn, Franz, Tegeler, Joachim, Schüssler, Gerhard
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Antipsychotic Agents - therapeutic use
Biological and medical sciences
Combined Modality Therapy
Female
Followup Studies
Germany
Hospitalization
Human
Humans
Life Change Events
Male
Medical sciences
Middle Aged
Patient Readmission
Prediction
Prospective Studies
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Psychotic Disorders - diagnosis
Psychotic Disorders - rehabilitation
Recurrence
Rehabilitation, Vocational
Relapse (Disorders)
Risk Factors
Schizoaffective Disorder
Schizophrenia
Schizophrenia - diagnosis
Schizophrenia - rehabilitation
Social Adjustment
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Summary:Abstract In a German multicenter treatment study, 354 patients with schizophrenia and schizoaffective disorder were followed for 2 years. The data collected were taken as a basis for the present predictor study. For the first time, the technique of classification and regression tree (CART) analysis has been employed for this purpose. CART yielded informative data and appeared to be a useful instrument in predictor research. On the outcome variables "relapse" and "rehospitalization," significant predictor variables were found in several areas: neuroleptic treatment, onset and previous course (precipitating factors, first manifestation, hospitalization in the preceding year, suicide attempts), psychopathology (residual type, schizoaffective disorder), social adjustment (marital status, employment, intensity of life, Phillips score), previous life experiences (traumatic experiences and psychiatric or developmental disturbances in childhood), and biology (gender, age). Our investigation confirmed the generally prevalent views regarding the value of neuroleptic treatment, the multifactorial etiology, and the vulnerability stress model of schizophrenia.
ISSN:0586-7614
1745-1701
DOI:10.1093/oxfordjournals.schbul.a033316