Omeprazole in infants with cimetidine-resistant peptic esophagitis

Twelve neurologically normal infants (age 2.9 ± 0.9 months) with peptic esophagitis (grade 2) who did not respond to cimetidine (in addition to positioning, cisapride, and Gaviscon) were treated with omeprazole, 0.5 mg/kg once a day, for 6 weeks. The effectiveness of omeprazole was evaluated in all...

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Bibliographic Details
Published in:The Journal of pediatrics 1998-02, Vol.132 (2), p.352-354
Main Authors: Alliët, Philippe, Raes, Marc, Bruneel, Els, Gillis, Philippe
Format: Article
Language:English
Subjects:
Anti-Ulcer Agents - therapeutic use
Biological and medical sciences
Cimetidine - therapeutic use
Digestive system
Esophagitis, Peptic - drug therapy
Gastroenterology. Liver. Pancreas. Abdomen
Histamine H2 Antagonists - therapeutic use
Humans
Infant
Medical sciences
Omeprazole - therapeutic use
Other diseases. Semiology
Pharmacology. Drug treatments
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Treatment Failure
Treatment Outcome
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Summary:Twelve neurologically normal infants (age 2.9 ± 0.9 months) with peptic esophagitis (grade 2) who did not respond to cimetidine (in addition to positioning, cisapride, and Gaviscon) were treated with omeprazole, 0.5 mg/kg once a day, for 6 weeks. The effectiveness of omeprazole was evaluated in all infants by clinical assessment and endoscopy before and after treatment and by 24-hour gastric pH monitoring during treatment in seven infants. Omeprazole therapy led to a marked decrease in symptoms, endoscopic and histologic signs of esophagitis, and intragastric acidity. (J Pediatr 1998;132:352-4)
ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(98)70460-3