Differential Involvement of Opioid Receptors in Intrathecal Butorphanol-Induced Analgesia: Compared to Morphine

The present experiments were performed to investigate the differential involvement of the opioid receptor subtypes in the antinociception of intrathecal (IT) butorphanol compared to IT morphine. A single dose (26 nmol) of IT nor-binaltorphimine (nor-BNI), β-funaltrexamine (β-FNA), and naltrindole (N...

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Bibliographic Details
Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 1998-03, Vol.59 (3), p.723-727
Main Authors: Wongchanapai, W, Tsang, B.K, He, Z, Ho, I.K
Format: Article
Language:English
Subjects:
Analgesics
Analgesics, Opioid - pharmacology
Animals
Antinociceptive
Biological and medical sciences
Butorphanol
Butorphanol - pharmacology
Dose-Response Relationship, Drug
Injections, Spinal
Intrathecal
Male
Medical sciences
Morphine
Morphine - pharmacology
Naltrexone - analogs & derivatives
Naltrexone - pharmacology
Narcotic Antagonists - pharmacology
Neuropharmacology
Pain Measurement - drug effects
Pharmacology. Drug treatments
Rats
Rats, Sprague-Dawley
Receptors, Opioid - drug effects
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Summary:The present experiments were performed to investigate the differential involvement of the opioid receptor subtypes in the antinociception of intrathecal (IT) butorphanol compared to IT morphine. A single dose (26 nmol) of IT nor-binaltorphimine (nor-BNI), β-funaltrexamine (β-FNA), and naltrindole (NTI) demonstrated a significant attenuation in the overall antinociception of IT butorphanol (52 nmol) or IT morphine (26 nmol). However, IT butorphanol elicits thermal antinociceptive effect through κ > δ ⩾ μ, whereas morphine acts on μ > δ >> κ. These results indicate that the antinociceptive effect of both IT butorphanol and IT morphine are mediated through μ, δ, and κ opioid receptors in different relative orders.
ISSN:0091-3057
1873-5177
DOI:10.1016/S0091-3057(97)00558-3