Inactivation of amoxycillin, clavulanate and the combination by faecal preparations from volunteers

Antibiotics active against Gram-positive bacteria often affect the anaerobic intestinal microflora and thus the colonization resistance. However, if such antibiotics are inactivated by enzymes in the intestine, they will not exert their negative influence on the anaerobic bacterial flora. The combin...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1990-02, Vol.25 (2), p.301-302
Main Authors: WELLING, GJALT W., GROEN, GERDA
Format: Article
Language:English
Subjects:
Amoxicillin - metabolism
beta-Lactamases - metabolism
Clavulanic Acid
Clavulanic Acids - metabolism
Feces - enzymology
Humans
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Summary:Antibiotics active against Gram-positive bacteria often affect the anaerobic intestinal microflora and thus the colonization resistance. However, if such antibiotics are inactivated by enzymes in the intestine, they will not exert their negative influence on the anaerobic bacterial flora. The combination of amoxycillin and clavulanate is active against amoxycillin-sensitive bacteria as well as many amoxycillin-resistant strains. We have investigated the inactivation of amoxycillin, clavulanate and the combination by faecal enzyme preparations from healthy volunteers.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/25.2.301