Antiatherosclerotic effect of Lipotab Forte in cholesterol-fed rabbits

The effect of Lipotab Forte, a new polypharmaceutical herbal formulation developed on the principles of the Unani system of medicine, was investigated on the progression of atherosclerosis in cholesterol fed rabbits. Retardation of the progression of atherosclerosis was observed in animals treated w...

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Bibliographic Details
Published in:Journal of ethnopharmacology 1998, Vol.59 (3), p.125-130
Main Authors: Raj kumar, S, Pillai, K.K, Balani, D.K, Hussain, S.Z
Format: Article
Language:English
Subjects:
Allium sativam
Allium sativum
Animals
Aorta - metabolism
Aorta - pathology
Arteriosclerosis - blood
Arteriosclerosis - pathology
Arteriosclerosis - therapy
Atherosclerosis
Biological and medical sciences
Cell Adhesion
Cholesterol - blood
Cholesterol - metabolism
Cholesterol, Dietary - administration & dosage
Curcuma longa
Female
General pharmacology
Lipotab Forte
Liver - metabolism
Liver - pathology
Male
Medical sciences
Nepeta
Nepeta hindustana
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Rabbits
Thiobarbituric Acid Reactive Substances - metabolism
traditional medicine
Triglycerides - blood
unani medicine
Unani System of medicine
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Summary:The effect of Lipotab Forte, a new polypharmaceutical herbal formulation developed on the principles of the Unani system of medicine, was investigated on the progression of atherosclerosis in cholesterol fed rabbits. Retardation of the progression of atherosclerosis was observed in animals treated with Lipotab Forte. The results were related to changes in the cholesterol content of aorta from the same animal. Blood cholesterol and triglyceride levels were greatly elevated in all rabbits on cholesterol feeding, but were significantly decreased by Lipotab Forte treatment. Lipotab Forte treatment also lowered aorta Thiobarbituric acid reactive substance (TBARS) levels from 79.72(±5.70) to 24.9 (±2.04) nmol/g of wet tissue and reduced hepatic cholesterol significantly in hypercholesterolemic rabbits.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(97)00105-0