African origin of GB virus C/hepatitis G virus

Ninety-four GB virus C/hepatitis G virus (GBV-C/HGV) RNA-positive serum samples were obtained from all over the world. We found that all 15 GBV-C/HGV isolates from the Pygmies and the Bantu in the Central African region had a 12-amino acid indel (i.e. insertion or deletion) in the non-structural pro...

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Bibliographic Details
Published in:FEBS letters 1998-02, Vol.423 (2), p.143-148
Main Authors: Tanaka, Yasuhito, Mizokami, Masashi, Orito, Etsuro, Ohba, Ken-ichi, Kato, Takanobu, Kondo, Yutaka, Mboudjeka, Innocent, Zekeng, Leopold, Kaptue, Lazare, Bikandou, Blaise, M'Pele, Pierre, Takehisa, Jun, Hayami, Masanori, Suzuki, Yoshiyuki, Gojobori, Takashi
Format: Article
Language:English
Subjects:
Africa
Amino Acid Sequence
Flaviviridae - chemistry
Flaviviridae - genetics
GB virus C
Genotype
Hepatitis G virus
Humans
Indel
Molecular Sequence Data
NS5A
Phylogenetic analysis
Phylogeny
Pygmy
RNA Helicases
RNA, Viral - chemistry
Sequence Alignment
Sequence Homology, Amino Acid
Serine Endopeptidases
Viral Nonstructural Proteins - genetics
Viral Proteins - chemistry
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Summary:Ninety-four GB virus C/hepatitis G virus (GBV-C/HGV) RNA-positive serum samples were obtained from all over the world. We found that all 15 GBV-C/HGV isolates from the Pygmies and the Bantu in the Central African region had a 12-amino acid indel (i.e. insertion or deletion) in the non-structural protein (NS) 5A region. Phylogenetic analyses of the NS5A region, using GBV-A as an outgroup, showed that these 15 isolates had diverged from the common ancestor much earlier than the remaining isolates, indicating an African origin of GBV-C/HGV.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(98)00083-0