Cytokines involved in human septic shock : the model of the Jarisch-Herxheimer reaction

Studies of the cytokine cascade in animal models of infection and human experiments involving endotoxin infusion have contributed fundamentally to understanding the role of cytokines in human sepsis. The complexity of this cytokine cascade has been difficult to unravel in clinical sepsis. However, t...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1998, Vol.41 (suppl 1), p.25-29
Main Author: GRIFFIN, G. E
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Pressure
Body Temperature
Cytokines - blood
Cytokines - metabolism
Disease Models, Animal
General aspects
Humans
Infection pathogenesis
Infectious diseases
Medical sciences
Penicillins - therapeutic use
Relapsing Fever - blood
Relapsing Fever - drug therapy
Sepsis - blood
Sepsis - drug therapy
Shock, Septic - blood
Shock, Septic - drug therapy
Shock, Septic - metabolism
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Summary:Studies of the cytokine cascade in animal models of infection and human experiments involving endotoxin infusion have contributed fundamentally to understanding the role of cytokines in human sepsis. The complexity of this cytokine cascade has been difficult to unravel in clinical sepsis. However, the Jarisch-Herxheimer reaction has been identified as a model of the cytokine cascade in human sepsis and has provided an excellent model for experiments involving blocking agents. TNF blocking has been shown to be important for protection in animal models of sepsis, but has been somewhat disappointing in humans because adverse events have generally outweighed benefits.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/41.suppl_1.25