Intrinsically bent DNA

Intrinsically bent or curved DNA molecules result when special base sequences or structural motifs are repeated in phase with the DNA helical repeat ( approximately equals 10.5 bp/turn). This places the recurrent elements along the same side of the double helix so that small bends associated with th...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of biological chemistry 1990-05, Vol.265 (13), p.7093-7096
Main Authors: CROTHERS, D. M, HARAN, T. E, NADEAU, J. G
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Base Composition
Biological and medical sciences
DNA - ultrastructure
Dna, deoxyribonucleoproteins
Fundamental and applied biological sciences. Psychology
Models, Molecular
Models, Theoretical
Nucleic Acid Conformation
Nucleic acids
Solutions
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Intrinsically bent or curved DNA molecules result when special base sequences or structural motifs are repeated in phase with the DNA helical repeat ( approximately equals 10.5 bp/turn). This places the recurrent elements along the same side of the double helix so that small bends associated with them add constructively to generate a large global curvature. Many base sequences can impart systematic curvature to DNA, but most such bends are small compared with the special effect produced by runs of homopolymeric dA multiplied by dT base pairs ("A-tracts"), each tract about half a helical turn long and repeated at 10-11-bp intervals.
ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(19)39080-5