Nuclear receptor that identifies a novel retinoic acid response pathway

Molecular cloning and transcriptional activation studies have revealed a new protein similar to the steroid hormone receptors and which responds specifically to vitamin A metabolites. This protein is substantially different in primary structure and ligand specificity from the products of the previou...

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Bibliographic Details
Published in:Nature (London) 1990-05, Vol.345 (6272), p.224-229
Main Authors: Mangelsdorf, David J, Ong, Estelita S, Dyck, Jacqueline A, Evans, Ronald M
Format: Article
Language:English
Subjects:
Acids
Adult
Amino Acid Sequence
Amino acids
Animals
Base Sequence
Biochemistry
Biological and medical sciences
Carrier Proteins - genetics
Carrier Proteins - metabolism
Cell Nucleus - metabolism
Cloning
Cloning, Molecular
Deoxyribonucleic acid
DNA
DNA - genetics
Drosophila - genetics
Fundamental and applied biological sciences. Psychology
Gene expression
Gene Expression Regulation - drug effects
Gene Library
Genes. Genome
Genetics
Hormones
Humanities and Social Sciences
Humans
Information Systems
Insects
Ligands
Male
Metabolites
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
multidisciplinary
Organ Specificity
Proteins
Rats
Receptors
Receptors, Retinoic Acid
Restriction Mapping
Retinoic acid
Science
Science (multidisciplinary)
Sequence Homology, Nucleic Acid
Steroid hormone receptors
Steroids
Thyroid gland
Transcription activation
Transcription factors
Transcription, Genetic
Tretinoin - metabolism
Tretinoin - pharmacology
Vitamin A
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Description
Summary:Molecular cloning and transcriptional activation studies have revealed a new protein similar to the steroid hormone receptors and which responds specifically to vitamin A metabolites. This protein is substantially different in primary structure and ligand specificity from the products of the previously described retinoic acid receptor gene family. By indicating the existence of an additional pathway through which retinoic acid may exert its effects, these data lead to a re-evaluation of retinoid physiology.
ISSN:0028-0836
1476-4687
DOI:10.1038/345224a0