The GABA-benzodiazepine interaction fifteen years later

The main steps are presented that led to our current understanding of the interaction between benzodiazepine receptor ligands and the GABAA receptor. The benzodiazepine receptor is a modulatory site located on the GABAA receptor-chloride channel complex that has the unique property of being able to...

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Bibliographic Details
Published in:Neurochemical research 1990-02, Vol.15 (2), p.169-174
Main Author: HAEFELY, W
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Central nervous system
Central neurotransmission. Neuromudulation. Pathways and receptors
Fundamental and applied biological sciences. Psychology
Nervous System - metabolism
Receptors, GABA-A - drug effects
Receptors, GABA-A - metabolism
Vertebrates: nervous system and sense organs
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Summary:The main steps are presented that led to our current understanding of the interaction between benzodiazepine receptor ligands and the GABAA receptor. The benzodiazepine receptor is a modulatory site located on the GABAA receptor-chloride channel complex that has the unique property of being able to mediate positive as well as negative modulation of the chloride channel gating by the GABAA receptor. Some critical issues concerning the structure of the receptor-channel complex remain to be clarified. Research on the benzodiazepine-GABA interaction has led to novel concepts of drug action and receptor function and provides the basis for a whole spectrum of potential drugs with therapeutic utility.
ISSN:0364-3190
1573-6903
DOI:10.1007/BF00972207