Local synthesis of amyloid fibril precursor in AL amyloidosis of the urinary tract

An amyloid tumor localized to the urethra was resected and shown by immunohistochemistry to contain fibril deposits that stained with antisera specific for λVI immunoglobulin light chain. The amino acid sequence of the fibril protein was homologous to λVI Positive staining of subepithelial plasma ce...

Full description

Saved in:
Bibliographic Details
Published in:Amyloid 1998-03, Vol.5 (1), p.49-54
Main Authors: Asl, Kamran Hamidi, Liepnieks, Juris J., Bihrle, Richard, Benson, Merrill D.
Format: Article
Language:English
Subjects:
Adult
Amino Acid Sequence
Amyloid - biosynthesis
Amyloid - chemistry
Amyloidosis - pathology
Humans
Immunoglobulin lambda-Chains - chemistry
Immunohistochemistry
Male
Molecular Sequence Data
Sequence Analysis
Urethra - pathology
Urogenital Neoplasms - chemistry
Urogenital Neoplasms - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An amyloid tumor localized to the urethra was resected and shown by immunohistochemistry to contain fibril deposits that stained with antisera specific for λVI immunoglobulin light chain. The amino acid sequence of the fibril protein was homologous to λVI Positive staining of subepithelial plasma cells with λVI specific monoclonal antibody was consistent with the hypothesis that the fibril precursor light chain protein is synthesized and processed locally to give this type of localized amyloidosis.
ISSN:1350-6129
1744-2818
DOI:10.3109/13506129809007290