Thalamic Amnesia Reconsidered: Excitotoxic Lesions of the Intralaminar Nuclei, but Not the Mediodorsal Nucleus, Disrupt Place Delayed Matching-to-Sample Performance in Rats (Rattus norvegicus)

• Published in: Behavioral neuroscience 1998-02, Vol.112 (1), p.54-67
• Main Authors: Burk, Joshua A, Mair, Robert G
• Format: Article
• Language: English
• Subjects: Anatomical correlates of behavior; Animal; Animals; Appetitive Behavior - physiology; Behavioral psychophysiology; Biological and medical sciences; Brain Mapping; Conditioning, Operant - physiology; Discrimination Learning - physiology; Frontal Lobe - physiology; Fundamental and applied biological sciences. Psychology; Male; Mental Recall - physiology; N-Methylaspartate; Neural Pathways - physiology; Neurology; Orientation - physiology; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychomotor Performance - physiology; Rats; Reaction Time - physiology; Retention; Reversal Learning - physiology; Rodents; Serial Learning - physiology; Thalamic Nuclei - physiology
• ISSN: 0735-7044; 1939-0084
• DOI: 10.1037/0735-7044.112.1.54

Rats with large thalamic lesions affecting the mediodorsal (MDn) and intralaminar (ILn) nuclei are impaired performing delayed matching to sample tasks (DMTS). To determine the neurological basis of this deficit, we trained rats to perform a place DMTS task and then compared the effects of excitotoxic lesions of the MDn, the ILn, and the lateral internal medullary lamina (L-IML). The MDn lesion had little effect. The ILn group was significantly impaired throughout 8 months of training. The L-IML group exhibited an intermediate level of impairment. Varying the sample response requirement, retention intervals, and trial-to-trial congruence in the side reinforced, had predicted effects, as did variations in response latency. However, none of these factors interacted with the treatment effects. These findings indicate that DMTS performance is disrupted by lesions of the ILn but not the MDn.