Effect of repeated oral infection of hamsters with scrapie

H Diringer, J Roehmel and M Beekes Robert Koch-Institut, Bundesinstitut fur Infektionskrankheiten und nicht ubertragbare Krankheiten, Berlin, Germany. The development of a transmissible spongiform encephalopathy upon uptake of the infectious agent in feed was studied in the model system scrapie in h...

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Bibliographic Details
Published in:Journal of general virology 1998-03, Vol.79 (3), p.609-612
Main Authors: Diringer, H, Roehmel, J, Beekes, M
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Cricetinae
Drug Administration Schedule
Injections
Scrapie - etiology
Scrapie - mortality
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Summary:H Diringer, J Roehmel and M Beekes Robert Koch-Institut, Bundesinstitut fur Infektionskrankheiten und nicht ubertragbare Krankheiten, Berlin, Germany. The development of a transmissible spongiform encephalopathy upon uptake of the infectious agent in feed was studied in the model system scrapie in hamsters. Compared to single dosing, repeated dosing caused disease at a considerable higher incidence. The risk of infection was higher when the time interval between repetitive dosing was short. There was a statistically significant trend of clearance of infectivity with time.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-79-3-609