Effect of repeated oral infection of hamsters with scrapie

H Diringer, J Roehmel and M Beekes Robert Koch-Institut, Bundesinstitut fur Infektionskrankheiten und nicht ubertragbare Krankheiten, Berlin, Germany. The development of a transmissible spongiform encephalopathy upon uptake of the infectious agent in feed was studied in the model system scrapie in h...

Full description

Saved in:
Bibliographic Details
Published in:Journal of general virology 1998-03, Vol.79 (3), p.609-612
Main Authors: Diringer, H, Roehmel, J, Beekes, M
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Cricetinae
Drug Administration Schedule
Injections
Scrapie - etiology
Scrapie - mortality
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c405t-8a94d01cba1d606bd13a752a51e73de852fd254a7ac02b9f48541517110e85593
cites
container_end_page 612
container_issue 3
container_start_page 609
container_title Journal of general virology
container_volume 79
creator Diringer, H
Roehmel, J
Beekes, M
description H Diringer, J Roehmel and M Beekes Robert Koch-Institut, Bundesinstitut fur Infektionskrankheiten und nicht ubertragbare Krankheiten, Berlin, Germany. The development of a transmissible spongiform encephalopathy upon uptake of the infectious agent in feed was studied in the model system scrapie in hamsters. Compared to single dosing, repeated dosing caused disease at a considerable higher incidence. The risk of infection was higher when the time interval between repetitive dosing was short. There was a statistically significant trend of clearance of infectivity with time.
doi_str_mv 10.1099/0022-1317-79-3-609
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79749325</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16414852</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-8a94d01cba1d606bd13a752a51e73de852fd254a7ac02b9f48541517110e85593</originalsourceid><addsrcrecordid>eNqFkE1LxDAQhoMo67r6BwShJz1VM2nSNN5kWT9gwYueQ9pOt5F-mXRd_Pem7LJXTwPzvPMMvIRcA70HqtQDpYzFkICMpYqTOKXqhMyBpyJmAZ-S-TFwTi68_6IUOBdyRmZKgMo4zMnjqqqwGKO-ihwOaEYso96ZJrLdtLd9N6HatH5E56OdHevIF84MFi_JWWUaj1eHuSCfz6uP5Wu8fn95Wz6t44JTMcaZUbykUOQGypSmeQmJkYIZASiTEjPBqpIJbqQpKMtVxTPBQYAEoAEKlSzI7d47uP57i37UrfUFNo3psN96LZXkKmHi3yCkHIKdhSDbBwvXe--w0oOzrXG_GqiemtVTcXoqLth1okOz4ejmYN_mLZbHk0OVgd_teW039c461BvsWhte5LbXP9YdTX825H_a</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16414852</pqid></control><display><type>article</type><title>Effect of repeated oral infection of hamsters with scrapie</title><source>Freely Accessible Journals</source><creator>Diringer, H ; Roehmel, J ; Beekes, M</creator><creatorcontrib>Diringer, H ; Roehmel, J ; Beekes, M</creatorcontrib><description>H Diringer, J Roehmel and M Beekes Robert Koch-Institut, Bundesinstitut fur Infektionskrankheiten und nicht ubertragbare Krankheiten, Berlin, Germany. The development of a transmissible spongiform encephalopathy upon uptake of the infectious agent in feed was studied in the model system scrapie in hamsters. Compared to single dosing, repeated dosing caused disease at a considerable higher incidence. The risk of infection was higher when the time interval between repetitive dosing was short. There was a statistically significant trend of clearance of infectivity with time.</description><identifier>ISSN: 0022-1317</identifier><identifier>EISSN: 1465-2099</identifier><identifier>DOI: 10.1099/0022-1317-79-3-609</identifier><identifier>PMID: 9519841</identifier><language>eng</language><publisher>England: Soc General Microbiol</publisher><subject>Administration, Oral ; Animals ; Cricetinae ; Drug Administration Schedule ; Injections ; Scrapie - etiology ; Scrapie - mortality</subject><ispartof>Journal of general virology, 1998-03, Vol.79 (3), p.609-612</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-8a94d01cba1d606bd13a752a51e73de852fd254a7ac02b9f48541517110e85593</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9519841$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diringer, H</creatorcontrib><creatorcontrib>Roehmel, J</creatorcontrib><creatorcontrib>Beekes, M</creatorcontrib><title>Effect of repeated oral infection of hamsters with scrapie</title><title>Journal of general virology</title><addtitle>J Gen Virol</addtitle><description>H Diringer, J Roehmel and M Beekes Robert Koch-Institut, Bundesinstitut fur Infektionskrankheiten und nicht ubertragbare Krankheiten, Berlin, Germany. The development of a transmissible spongiform encephalopathy upon uptake of the infectious agent in feed was studied in the model system scrapie in hamsters. Compared to single dosing, repeated dosing caused disease at a considerable higher incidence. The risk of infection was higher when the time interval between repetitive dosing was short. There was a statistically significant trend of clearance of infectivity with time.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Cricetinae</subject><subject>Drug Administration Schedule</subject><subject>Injections</subject><subject>Scrapie - etiology</subject><subject>Scrapie - mortality</subject><issn>0022-1317</issn><issn>1465-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LxDAQhoMo67r6BwShJz1VM2nSNN5kWT9gwYueQ9pOt5F-mXRd_Pem7LJXTwPzvPMMvIRcA70HqtQDpYzFkICMpYqTOKXqhMyBpyJmAZ-S-TFwTi68_6IUOBdyRmZKgMo4zMnjqqqwGKO-ihwOaEYso96ZJrLdtLd9N6HatH5E56OdHevIF84MFi_JWWUaj1eHuSCfz6uP5Wu8fn95Wz6t44JTMcaZUbykUOQGypSmeQmJkYIZASiTEjPBqpIJbqQpKMtVxTPBQYAEoAEKlSzI7d47uP57i37UrfUFNo3psN96LZXkKmHi3yCkHIKdhSDbBwvXe--w0oOzrXG_GqiemtVTcXoqLth1okOz4ejmYN_mLZbHk0OVgd_teW039c461BvsWhte5LbXP9YdTX825H_a</recordid><startdate>19980301</startdate><enddate>19980301</enddate><creator>Diringer, H</creator><creator>Roehmel, J</creator><creator>Beekes, M</creator><general>Soc General Microbiol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19980301</creationdate><title>Effect of repeated oral infection of hamsters with scrapie</title><author>Diringer, H ; Roehmel, J ; Beekes, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-8a94d01cba1d606bd13a752a51e73de852fd254a7ac02b9f48541517110e85593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Cricetinae</topic><topic>Drug Administration Schedule</topic><topic>Injections</topic><topic>Scrapie - etiology</topic><topic>Scrapie - mortality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diringer, H</creatorcontrib><creatorcontrib>Roehmel, J</creatorcontrib><creatorcontrib>Beekes, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of general virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diringer, H</au><au>Roehmel, J</au><au>Beekes, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of repeated oral infection of hamsters with scrapie</atitle><jtitle>Journal of general virology</jtitle><addtitle>J Gen Virol</addtitle><date>1998-03-01</date><risdate>1998</risdate><volume>79</volume><issue>3</issue><spage>609</spage><epage>612</epage><pages>609-612</pages><issn>0022-1317</issn><eissn>1465-2099</eissn><abstract>H Diringer, J Roehmel and M Beekes Robert Koch-Institut, Bundesinstitut fur Infektionskrankheiten und nicht ubertragbare Krankheiten, Berlin, Germany. The development of a transmissible spongiform encephalopathy upon uptake of the infectious agent in feed was studied in the model system scrapie in hamsters. Compared to single dosing, repeated dosing caused disease at a considerable higher incidence. The risk of infection was higher when the time interval between repetitive dosing was short. There was a statistically significant trend of clearance of infectivity with time.</abstract><cop>England</cop><pub>Soc General Microbiol</pub><pmid>9519841</pmid><doi>10.1099/0022-1317-79-3-609</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0022-1317
ispartof Journal of general virology, 1998-03, Vol.79 (3), p.609-612
issn 0022-1317
1465-2099
language eng
recordid cdi_proquest_miscellaneous_79749325
source Freely Accessible Journals
subjects Administration, Oral
Animals
Cricetinae
Drug Administration Schedule
Injections
Scrapie - etiology
Scrapie - mortality
title Effect of repeated oral infection of hamsters with scrapie
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T01%3A15%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20repeated%20oral%20infection%20of%20hamsters%20with%20scrapie&rft.jtitle=Journal%20of%20general%20virology&rft.au=Diringer,%20H&rft.date=1998-03-01&rft.volume=79&rft.issue=3&rft.spage=609&rft.epage=612&rft.pages=609-612&rft.issn=0022-1317&rft.eissn=1465-2099&rft_id=info:doi/10.1099/0022-1317-79-3-609&rft_dat=%3Cproquest_cross%3E16414852%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c405t-8a94d01cba1d606bd13a752a51e73de852fd254a7ac02b9f48541517110e85593%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=16414852&rft_id=info:pmid/9519841&rfr_iscdi=true