Characterization of Submicron Systems via Optical Methods

□ As a means of addressing the issues of drug delivery, submicron colloidal systems have become increasingly used as pharmaceutical formulations. Accurately characterizing physical properties of the constituent particulates present in these systems is an indispensable activity. However, measuring de...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1998-02, Vol.87 (2), p.125-129
Main Author: Haskell, Roy J.
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
Chemical Phenomena
Chemistry Techniques, Analytical - methods
Chemistry, Pharmaceutical
Chemistry, Physical
Colloids - chemistry
Drug Carriers
General pharmacology
Liposomes
Medical sciences
Nephelometry and Turbidimetry
Optics and Photonics
Particle Size
Pharmacology. Drug treatments
Static Electricity
Statistical Distributions
Surface Properties
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Summary:□ As a means of addressing the issues of drug delivery, submicron colloidal systems have become increasingly used as pharmaceutical formulations. Accurately characterizing physical properties of the constituent particulates present in these systems is an indispensable activity. However, measuring descriptors such as particle size distribution and surface potential presents an experimental challenge. This paper describes the physical basis for a number of optically based techniques that are useful in this task. In addition, the caveats and benefits of these methods are discussed and reference is made to their use in the examination of various multiphase systems such as liposomes, nanoparticles, and emulsions.
ISSN:0022-3549
1520-6017
DOI:10.1021/js970331i