Prevalence of congenital adrenal hyperplasia in Kuwait

Between 1978 and 1988 congenital adrenal hyperplasia (CAH) was diagnosed in 60 children in Kuwait with an estimated prevalence of 1:9,000 livebirths, which is higher than that reported from Europe and Canada. In addition, there was presumptive evidence of CAH resulting in the death of 20 other child...

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Bibliographic Details
Published in:European journal of pediatrics 1990-03, Vol.149 (6), p.391-392
Main Authors: Lubani, M M, Issa, A R, Bushnaq, R, al-Saleh, Q A, Dudin, K I, Reavey, P C, el-Khalifa, M Y, Manandhar, D S, Abdul Al, Y K, Ismail, E A
Format: Article
Language:English
Subjects:
Adrenal Hyperplasia, Congenital - epidemiology
Adrenal Hyperplasia, Congenital - mortality
Adrenal Hyperplasia, Congenital - physiopathology
Canada - epidemiology
Child
Europe - epidemiology
Female
Humans
Kuwait - epidemiology
Male
Prevalence
Steroid Hydroxylases - deficiency
United States - epidemiology
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Summary:Between 1978 and 1988 congenital adrenal hyperplasia (CAH) was diagnosed in 60 children in Kuwait with an estimated prevalence of 1:9,000 livebirths, which is higher than that reported from Europe and Canada. In addition, there was presumptive evidence of CAH resulting in the death of 20 other children, giving a prevalence figure of 1:7000. There were 41 girls (68%) and 19 boys (32%). Thirty-one of the girls (75.6%) and 11 of the boys (57.9%) were saltlosers. Fifty-four patients (90%) were diagnosed as 21-hydroxylase deficient, 3 patients (5%) had a deficiency of the 3 beta-hydroxy-steroid dehydrogenase enzyme, and 3 patients (5%) showed a deficiency of 11 beta-hydroxylase.
ISSN:0340-6199
1432-1076
DOI:10.1007/BF02009655