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Evidence for deficiencies in intracerebral cytokine production, adhesion molecule induction, and T cell recruitment in herpes simplex virus type-2 infected mice
We examined the intracerebral T cell response in mice infected with neurovirulent HSV-2 strains and an avirulent HSV-1. In HSV-2-infected brains, (i) IL-1 β, TNF- α and IFN- γ mRNA expression was low, (ii) ICAM-1 and VCAM-1 were not induced, (iii) few CD4 + or CD8 + cells were detected. By contrast,...
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Published in: | Journal of neuroimmunology 1998, Vol.81 (1), p.58-65 |
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container_title | Journal of neuroimmunology |
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creator | Lewandowski, Gail Hobbs, Monte V |
description | We examined the intracerebral T cell response in mice infected with neurovirulent HSV-2 strains and an avirulent HSV-1. In HSV-2-infected brains, (i) IL-1
β, TNF-
α and IFN-
γ mRNA expression was low, (ii) ICAM-1 and VCAM-1 were not induced, (iii) few CD4
+ or CD8
+ cells were detected. By contrast, in HSV-1-infected brains, (i) cytokine mRNA expression was high, (ii) adhesion molecules were strongly expressed, (iii) many T cells were detected. We suggest that deficient T cell extravasation into HSV-2-infected brain regions is caused by negligible ICAM-1 and VCAM-1 expression, which is due to low expression of critical cytokines. |
doi_str_mv | 10.1016/S0165-5728(97)00159-8 |
format | article |
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β, TNF-
α and IFN-
γ mRNA expression was low, (ii) ICAM-1 and VCAM-1 were not induced, (iii) few CD4
+ or CD8
+ cells were detected. By contrast, in HSV-1-infected brains, (i) cytokine mRNA expression was high, (ii) adhesion molecules were strongly expressed, (iii) many T cells were detected. We suggest that deficient T cell extravasation into HSV-2-infected brain regions is caused by negligible ICAM-1 and VCAM-1 expression, which is due to low expression of critical cytokines.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/S0165-5728(97)00159-8</identifier><identifier>PMID: 9521606</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Brain ; Brain - metabolism ; Cell Adhesion Molecules - biosynthesis ; Cell Adhesion Molecules - genetics ; Cercopithecus aethiops - genetics ; Cytokines - biosynthesis ; Cytokines - genetics ; Encephalitis, Viral - immunology ; Encephalitis, Viral - metabolism ; Gene Expression ; Herpes Simplex - classification ; Herpes Simplex - immunology ; Herpes Simplex - metabolism ; Immunosuppression ; Intercellular Adhesion Molecule-1 - biosynthesis ; Intercellular Adhesion Molecule-1 - genetics ; Interferon-gamma - biosynthesis ; Interferon-gamma - genetics ; Interleukin-1 - biosynthesis ; Interleukin-1 - genetics ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neural-immune ; Neuropathogenesis ; RNA, Messenger - biosynthesis ; RNA, Messenger - genetics ; Simplexvirus - pathogenicity ; T-Lymphocyte Subsets - immunology ; Tumor Necrosis Factor-alpha - biosynthesis ; Tumor Necrosis Factor-alpha - genetics ; Vascular Cell Adhesion Molecule-1 - biosynthesis ; Vascular Cell Adhesion Molecule-1 - genetics ; Vero Cells ; Virulence</subject><ispartof>Journal of neuroimmunology, 1998, Vol.81 (1), p.58-65</ispartof><rights>1998 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-8cca2526babea640a846453f8bd62c30b2b866d1445aa309758731ba54963c283</citedby><cites>FETCH-LOGICAL-c391t-8cca2526babea640a846453f8bd62c30b2b866d1445aa309758731ba54963c283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9521606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lewandowski, Gail</creatorcontrib><creatorcontrib>Hobbs, Monte V</creatorcontrib><title>Evidence for deficiencies in intracerebral cytokine production, adhesion molecule induction, and T cell recruitment in herpes simplex virus type-2 infected mice</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>We examined the intracerebral T cell response in mice infected with neurovirulent HSV-2 strains and an avirulent HSV-1. In HSV-2-infected brains, (i) IL-1
β, TNF-
α and IFN-
γ mRNA expression was low, (ii) ICAM-1 and VCAM-1 were not induced, (iii) few CD4
+ or CD8
+ cells were detected. By contrast, in HSV-1-infected brains, (i) cytokine mRNA expression was high, (ii) adhesion molecules were strongly expressed, (iii) many T cells were detected. We suggest that deficient T cell extravasation into HSV-2-infected brain regions is caused by negligible ICAM-1 and VCAM-1 expression, which is due to low expression of critical cytokines.</description><subject>Animals</subject><subject>Brain</subject><subject>Brain - metabolism</subject><subject>Cell Adhesion Molecules - biosynthesis</subject><subject>Cell Adhesion Molecules - genetics</subject><subject>Cercopithecus aethiops - genetics</subject><subject>Cytokines - biosynthesis</subject><subject>Cytokines - genetics</subject><subject>Encephalitis, Viral - immunology</subject><subject>Encephalitis, Viral - metabolism</subject><subject>Gene Expression</subject><subject>Herpes Simplex - classification</subject><subject>Herpes Simplex - immunology</subject><subject>Herpes Simplex - metabolism</subject><subject>Immunosuppression</subject><subject>Intercellular Adhesion Molecule-1 - biosynthesis</subject><subject>Intercellular Adhesion Molecule-1 - genetics</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Interferon-gamma - genetics</subject><subject>Interleukin-1 - biosynthesis</subject><subject>Interleukin-1 - genetics</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Neural-immune</subject><subject>Neuropathogenesis</subject><subject>RNA, Messenger - biosynthesis</subject><subject>RNA, Messenger - genetics</subject><subject>Simplexvirus - pathogenicity</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>Tumor Necrosis Factor-alpha - biosynthesis</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><subject>Vascular Cell Adhesion Molecule-1 - biosynthesis</subject><subject>Vascular Cell Adhesion Molecule-1 - genetics</subject><subject>Vero Cells</subject><subject>Virulence</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqFUV1rHCEUldKSbtL-hIBPpYVMoo46-lRCSNtAoA9Jn8XRO8R2vqrO0v03_al1dpf0MSB-cM6553oPQueUXFJC5dVD2UQlGqY-6uYTIVToSr1CG6oaVinO6Gu0eaa8Racp_VxJNdcn6EQLRiWRG_T3dhs8jA5wN0XsoQsulGeAhMNYVo7WQYQ22h67XZ5-hRHwHCe_uBym8QJb_wSp3PAw9eCWHoroPzh6_Igd9D2O4OIS8gBjXis_QZyLRwrD3MMfvA1xSTjvZqhYgTtwGTwegoN36E1n-wTvj-cZ-vHl9vHmW3X__evdzfV95WpNc6Wcs0ww2doWrOTEKi65qDvVeslcTVrWKik95VxYWxPdCNXUtLWCa1k7puoz9OFQt3zu9wIpmyGktXM7wrQk0xQJJ0q-SKSSaaL1ShQHootTShE6M8cw2LgzlJg1QrOP0Kz5GN2YfYRm7eT8aLC0A_hn1TGzgn8-4FDGsQ0QTdpnBj6UIWfjp_CCwz8gna4o</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>Lewandowski, Gail</creator><creator>Hobbs, Monte V</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1998</creationdate><title>Evidence for deficiencies in intracerebral cytokine production, adhesion molecule induction, and T cell recruitment in herpes simplex virus type-2 infected mice</title><author>Lewandowski, Gail ; Hobbs, Monte V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-8cca2526babea640a846453f8bd62c30b2b866d1445aa309758731ba54963c283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Brain</topic><topic>Brain - metabolism</topic><topic>Cell Adhesion Molecules - biosynthesis</topic><topic>Cell Adhesion Molecules - genetics</topic><topic>Cercopithecus aethiops - genetics</topic><topic>Cytokines - biosynthesis</topic><topic>Cytokines - genetics</topic><topic>Encephalitis, Viral - immunology</topic><topic>Encephalitis, Viral - metabolism</topic><topic>Gene Expression</topic><topic>Herpes Simplex - classification</topic><topic>Herpes Simplex - immunology</topic><topic>Herpes Simplex - metabolism</topic><topic>Immunosuppression</topic><topic>Intercellular Adhesion Molecule-1 - biosynthesis</topic><topic>Intercellular Adhesion Molecule-1 - genetics</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Interferon-gamma - genetics</topic><topic>Interleukin-1 - biosynthesis</topic><topic>Interleukin-1 - genetics</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Neural-immune</topic><topic>Neuropathogenesis</topic><topic>RNA, Messenger - biosynthesis</topic><topic>RNA, Messenger - genetics</topic><topic>Simplexvirus - pathogenicity</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>Tumor Necrosis Factor-alpha - biosynthesis</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><topic>Vascular Cell Adhesion Molecule-1 - biosynthesis</topic><topic>Vascular Cell Adhesion Molecule-1 - genetics</topic><topic>Vero Cells</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lewandowski, Gail</creatorcontrib><creatorcontrib>Hobbs, Monte V</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lewandowski, Gail</au><au>Hobbs, Monte V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for deficiencies in intracerebral cytokine production, adhesion molecule induction, and T cell recruitment in herpes simplex virus type-2 infected mice</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>1998</date><risdate>1998</risdate><volume>81</volume><issue>1</issue><spage>58</spage><epage>65</epage><pages>58-65</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>We examined the intracerebral T cell response in mice infected with neurovirulent HSV-2 strains and an avirulent HSV-1. In HSV-2-infected brains, (i) IL-1
β, TNF-
α and IFN-
γ mRNA expression was low, (ii) ICAM-1 and VCAM-1 were not induced, (iii) few CD4
+ or CD8
+ cells were detected. By contrast, in HSV-1-infected brains, (i) cytokine mRNA expression was high, (ii) adhesion molecules were strongly expressed, (iii) many T cells were detected. We suggest that deficient T cell extravasation into HSV-2-infected brain regions is caused by negligible ICAM-1 and VCAM-1 expression, which is due to low expression of critical cytokines.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>9521606</pmid><doi>10.1016/S0165-5728(97)00159-8</doi><tpages>8</tpages></addata></record> |
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subjects | Animals Brain Brain - metabolism Cell Adhesion Molecules - biosynthesis Cell Adhesion Molecules - genetics Cercopithecus aethiops - genetics Cytokines - biosynthesis Cytokines - genetics Encephalitis, Viral - immunology Encephalitis, Viral - metabolism Gene Expression Herpes Simplex - classification Herpes Simplex - immunology Herpes Simplex - metabolism Immunosuppression Intercellular Adhesion Molecule-1 - biosynthesis Intercellular Adhesion Molecule-1 - genetics Interferon-gamma - biosynthesis Interferon-gamma - genetics Interleukin-1 - biosynthesis Interleukin-1 - genetics Mice Mice, Inbred BALB C Mice, Nude Neural-immune Neuropathogenesis RNA, Messenger - biosynthesis RNA, Messenger - genetics Simplexvirus - pathogenicity T-Lymphocyte Subsets - immunology Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics Vascular Cell Adhesion Molecule-1 - biosynthesis Vascular Cell Adhesion Molecule-1 - genetics Vero Cells Virulence |
title | Evidence for deficiencies in intracerebral cytokine production, adhesion molecule induction, and T cell recruitment in herpes simplex virus type-2 infected mice |
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