Inducement of Neisseria meningitidis Resistance to Ampicillin and Penicillin in a Patient with Meningococcemia Treated with High Doses of Ampicillin

Neisseria meningitidis strains with moderate or relative resistance to penicillin (defined as a penicillin MIC of 0.1-1.0 mu g/mL) also have decreased susceptibility to ampicillin and have been reported from a wide variety of geographic locations. Penicillin resistance in N. meningitidis is due at l...

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Bibliographic Details
Published in:Clinical infectious diseases 1998-03, Vol.26 (3), p.772-772
Main Author: GOLDANI, L. Z
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Ampicillin - therapeutic use
Ampicillin Resistance
Bacteremia - drug therapy
Bacterial diseases
Bacterial sepsis
Biological and medical sciences
Brief Reports
Fatal Outcome
Female
Human bacterial diseases
Humans
Infectious diseases
Medical sciences
Meningococcal Infections - drug therapy
Neisseria meningitidis
Neisseria meningitidis - drug effects
Penicillin
Penicillin Resistance
Penicillins - therapeutic use
Tropical medicine
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Summary:Neisseria meningitidis strains with moderate or relative resistance to penicillin (defined as a penicillin MIC of 0.1-1.0 mu g/mL) also have decreased susceptibility to ampicillin and have been reported from a wide variety of geographic locations. Penicillin resistance in N. meningitidis is due at least in part to altered penicillin-binding protein (PBP) 2. The PBP 2 alteration results from altered nucleotide sequence of the PBP 2 gene, penA. High-level penicillin resistance due to beta -lactamase production has also been reported, and the MICs for these N. meningitidis strains may be as high as 256 mu g/mL.
ISSN:1058-4838
1537-6591
DOI:10.1086/517128