Impaired spatial working and reference memory in segmental trisomy (Ts65Dn) mice

To evaluate the cognitive phenotype of the segmental trisomy 16 (Ts65Dn) mouse, a model of Down Syndrome (DS, trisomy 21), we assessed spatial working and reference memory using a 12-arm radial maze (RAM). Ts65Dn mice made a greater number of reference memory errors across trials compared to control...

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Bibliographic Details
Published in:Behavioural brain research 1998-02, Vol.90 (2), p.199-201
Main Authors: Demas, Gregory E, Nelson, Randy J, Krueger, Bruce K, Yarowsky, Paul J
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chromosome aberrations
Cognition Disorders - genetics
Cognition Disorders - psychology
Down syndrome
Learning
Male
Medical genetics
Medical sciences
Memory
Memory - physiology
Memory Disorders - genetics
Memory Disorders - psychology
Mice
Mice, Neurologic Mutants
Space Perception - physiology
Trisomy - genetics
Trisomy - physiopathology
Trisomy 16
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Summary:To evaluate the cognitive phenotype of the segmental trisomy 16 (Ts65Dn) mouse, a model of Down Syndrome (DS, trisomy 21), we assessed spatial working and reference memory using a 12-arm radial maze (RAM). Ts65Dn mice made a greater number of reference memory errors across trials compared to control mice. Both genotypes showed improvement across trials, although improvement was slower in Ts65Dn mice. Ts65Dn mice also made a greater number of working memory errors on the RAM, and in contrast to control mice, did not improve across trials, always performing at near-chance levels. These results provide evidence for both spatial working and reference memory deficits in Ts65Dn mice, characteristics of cognitive dysfunction.
ISSN:0166-4328
1872-7549
DOI:10.1016/S0166-4328(97)00116-2