The pathogenetic role of HLA-B27 in chronic arthritis

Population and peptide specificity analyses and studies in transgenic rodents support a role of HLA-B27 as an antigen-presenting molecule in spondyloarthropathy. The interplay between HLA-B27 and arthritogenic bacteria on infected cells suggests that HLA-B27 might also influence disease by other mec...

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Bibliographic Details
Published in:Current opinion in immunology 1998-02, Vol.10 (1), p.59-66
Main Author: de Castro, JALopez
Format: Article
Language:English
Subjects:
Animals
Animals, Genetically Modified
Arthritis - genetics
Arthritis - physiopathology
Bacterial Infections - immunology
Chronic Disease
Cysteine - immunology
HLA-B27 Antigen - genetics
HLA-B27 Antigen - immunology
HLA-B27 Antigen - physiology
Humans
Peptides - immunology
Polymorphism, Genetic
Spinal Diseases - immunology
Spondylitis, Ankylosing - genetics
Spondylitis, Ankylosing - physiopathology
T-Lymphocytes - immunology
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Summary:Population and peptide specificity analyses and studies in transgenic rodents support a role of HLA-B27 as an antigen-presenting molecule in spondyloarthropathy. The interplay between HLA-B27 and arthritogenic bacteria on infected cells suggests that HLA-B27 might also influence disease by other mechanisms. Recent genetic advances promise the identification of additional susceptibility genes.
ISSN:0952-7915
1879-0372
DOI:10.1016/S0952-7915(98)80033-2