Variable effect of streptozotocin-diabetes on the growth of hamster pancreatic cancer (H2T) in the Syrian hamster and nude mouse

Background: Streptozotocin-diabetes prevents induction of pancreatic tumors in several animal models and inhibits the growth of established human pancreatic cancer implants in nude mice. However, it also promotes growth of the hamster pancreatic cancer cell line, H2T, in the Syrian hamster. To test...

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Bibliographic Details
Published in:Surgery 1998-03, Vol.123 (3), p.315-320
Main Authors: Fisher, William E., Muscarella, Peter, Boros, Laszlo G., Schirmer, William J.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Body Weight
Cricetinae
Diabetes Mellitus, Experimental - complications
Gastroenterology. Liver. Pancreas. Abdomen
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Mesocricetus
Mice
Mice, Nude
Neoplasm Transplantation
Pancreatic Neoplasms - complications
Pancreatic Neoplasms - pathology
Receptor, IGF Type 1 - metabolism
Receptor, Insulin - metabolism
Receptors, Glucagon - metabolism
Receptors, Somatostatin - metabolism
Transplantation, Heterologous
Tumor Cells, Cultured
Tumors
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Summary:Background: Streptozotocin-diabetes prevents induction of pancreatic tumors in several animal models and inhibits the growth of established human pancreatic cancer implants in nude mice. However, it also promotes growth of the hamster pancreatic cancer cell line, H2T, in the Syrian hamster. To test the hypothesis that these contradictory effects are due to tumor host differences, the growth of the H2T cell line was examined in the streptozotocin-diabetic nude mouse. Methods: H2T cells were implanted subcutaneously into streptozotocin-diabetic nude mice ( n = 10) and untreated control mice ( n = 10). After 21 days, tumors were excised and weighed. Plasma insulin and somatostatin were determined by radioimmunoassay. Results: After 3 weeks, tumors in the control group weighed 118 mg and tumors in the diabetic group weighed 28 mg ( p < 0.001). Plasma insulin was significantly decreased in the streptozotocin-treated animals compared with control animals (insulin, 23 μ U/ml vs 31 μ U/ml; p < 0.001). In contrast, somatostatin was significantly elevated in the streptozotocin-diabetic group compared with the control group (somatostatin, 179 pg/ml versus 54 pg/ml, p
ISSN:0039-6060
1532-7361
DOI:10.1016/S0039-6060(98)70185-0