Contributions of tidal lung inflation to human R–R interval and arterial pressure fluctuations

• Published in: Journal of the autonomic nervous system 1998-01, Vol.68 (1), p.89-95
• Main Authors: Koh, Junken, Brown, Troy E, Beightol, Larry A, Eckberg, Dwain L
• Format: Article
• Language: English
• Subjects: Adult; Algorithms; Arrhythmias, Cardiac - physiopathology; Arteries - physiology; Biological and medical sciences; Blood Pressure - physiology; Electric Stimulation; Electrocardiography; Female; Fentanyl; Fundamental and applied biological sciences. Psychology; Heart Rate - physiology; High frequency jet ventilation; Humans; Lung - physiology; Male; Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ; Respiratory Mechanics - physiology; Respiratory sinus arrhythmia; Sedation; Space life sciences; Tidal Volume - physiology; Vecuronium; Vertebrates: nervous system and sense organs
• ISSN: 0165-1838; 1872-7476
• DOI: 10.1016/S0165-1838(97)00114-8

We studied the effects of mechanical lung inflation on respiratory frequency R–R interval and arterial pressure fluctuations in nine healthy young adults undergoing elective orthopedic surgery. We conducted this research to define the contribution of pulmonary and thoracic stretch receptor input to respiratory sinus arrhythmia. We compared fast Fourier transform spectral power during three modes of ventilation: (1) spontaneous, frequency-controlled (0.25 Hz) breathing, (2) intermittent positive pressure ventilation (0.25 Hz, with a tidal volume of 8 ml/kg) and (3) high frequency jet ventilation (5.0 Hz, 2.5 kg/cm 2), after sedation and vecuronium paralysis. Mean R–R intervals, arterial pressures and arterial blood gas levels were comparable during all three breathing conditions. Respiratory frequency systolic pressure spectral power was comparable during spontaneous breathing and conventional mechanical ventilation, but was significantly reduced during high frequency jet ventilation ( P