CD4 and CD8: modulators of T-cell receptor recognition of antigen and of immune responses?

The response of T cells to antigen involves the participation of a number of distinct receptor-ligand engagements. The major players in the recognition of complexes of major histocompatibility complex molecules and peptide antigens are the T-cell receptors and the co-receptors CD4 and CD8. Progress...

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Bibliographic Details
Published in:Current opinion in immunology 1998-02, Vol.10 (1), p.82-87
Main Author: Zamoyska, Rose
Format: Article
Language:English
Subjects:
abr APL altered peptide ligand
Animals
Antigens - immunology
CD4 Antigens - immunology
CD8 Antigens - immunology
CDR complementarity determining region
Cell Differentiation
Clonal Anergy - immunology
Humans
Lymphocyte Activation - immunology
Major Histocompatibility Complex - immunology
MHC major histocompatibility complex
Receptors, Antigen, T-Cell - immunology
T-Lymphocytes, Regulatory - immunology
TCR T-cell receptor
Tg-TCR transgene-encoded T-cell receptor
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Summary:The response of T cells to antigen involves the participation of a number of distinct receptor-ligand engagements. The major players in the recognition of complexes of major histocompatibility complex molecules and peptide antigens are the T-cell receptors and the co-receptors CD4 and CD8. Progress in understanding the physical structures of these molecules, and how complexes between them are formed, is helping our understanding of how they participate in regulating the signals transduced to T cells.
ISSN:0952-7915
1879-0372
DOI:10.1016/S0952-7915(98)80036-8