Striated muscle calcium-stimulated cysteine protease (calpain-like) activity promotes myeloperoxidase activity with exercise

An inflammatory response triggered by neutrophil accumulation into muscle tissue is thought to occur with exercise-induced muscle damage. To investigate the relationship between Ca2+-stimulated proteolysis (calpain-like activity) and neutrophil accumulation [myeloperoxidase (MPO) activity], cardiac...

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Bibliographic Details
Published in:Pflügers Archiv 1998-05, Vol.435 (6), p.804-809
Main Authors: Raj, D A, Booker, T S, Belcastro, A N
Format: Article
Language:English
Subjects:
Animals
Calpain - metabolism
Creatine Kinase - blood
Cysteine Proteinase Inhibitors - pharmacology
Leucine - analogs & derivatives
Leucine - pharmacology
Male
Muscle, Skeletal - enzymology
Myocardium - enzymology
Neutrophils - enzymology
Neutrophils - physiology
Peroxidase - metabolism
Physical Exertion - physiology
Rats
Rats, Wistar
Space life sciences
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Summary:An inflammatory response triggered by neutrophil accumulation into muscle tissue is thought to occur with exercise-induced muscle damage. To investigate the relationship between Ca2+-stimulated proteolysis (calpain-like activity) and neutrophil accumulation [myeloperoxidase (MPO) activity], cardiac and plantaris muscles from rats (n = 10) completing 1 h exercise (25 m/min) were investigated. Exercise promoted increases (P
ISSN:0031-6768
1432-2013
DOI:10.1007/s004240050587