Tissue-Specific Recognition of Mouse CD1 Molecules

Although there is evidence that some members of the CD1 gene family may present particular types of foreign Ags, such as mycobacterial lipid Ags or synthetic hydrophobic peptides, to alphabeta T cells, most CD1 isotypes share the unusual property of being recognized by a high frequency of naturally...

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Bibliographic Details
Published in:The Journal of immunology (1950) 1998-04, Vol.160 (7), p.3128-3134
Main Authors: Park, Se-Ho, Roark, Jessica H, Bendelac, Albert
Format: Article
Language:English
Subjects:
Animals
Antigens, CD1 - immunology
Antigens, CD1 - metabolism
Antiporters
Carrier Proteins - physiology
Epitopes - immunology
Hybridomas
Immunoglobulins
Membrane Transport Proteins
Mice
Mice, Inbred AKR
Mice, Inbred BALB C
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Inbred DBA
Mice, Inbred NOD
Mice, Inbred NZB
Mice, Knockout
Organ Specificity - immunology
Rats
Spleen - cytology
T-Lymphocytes - metabolism
Thymus Gland - cytology
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Summary:Although there is evidence that some members of the CD1 gene family may present particular types of foreign Ags, such as mycobacterial lipid Ags or synthetic hydrophobic peptides, to alphabeta T cells, most CD1 isotypes share the unusual property of being recognized by a high frequency of naturally autoreactive alphabeta T cells. In the case of mouse CD1.1 and its human counterpart CD1d, a significant fraction of the autoreactive T cells express semi-invariant TCRs. CD1.1-specific T cells have a restricted tissue distribution and very promptly secrete a large panel of potent cytokines, including IL-4 and IFN-gamma, upon primary activation through their TCR, suggesting that they might regulate some immune responses in these tissues. We show here that their autorecognition of mouse CD1.1 is highly dependent upon the cell type in which CD1.1 is expressed. For example, some of these T cells only respond to CD1.1 expressed by splenic dendritic cells, some respond preferentially to cortical thymocytes, and others respond to splenic B cells. Tissue specificity of CD1.1 recognition is also observed with various cell lines transfected with CD1.1 cDNA. These results show that different CD1.1 self Ags are expressed in different tissues and can be specifically recognized by autoreactive T cells. They suggest that CD1.1 may be naturally associated with a variety of self ligands that overlap only partially in different cell types.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.160.7.3128