Histone Deacetylase Inhibitors Up-regulate the Expression of Cell Surface MHC Class-I Molecules in B16/BL6 Cells

• Published in: Journal of antibiotics 1998/01/25, Vol.51(1), pp.89-91
• Main Authors: KOMATSU, YASUHIKO, HAYASHI, HIDEYA
• Format: Article
• Language: English
• Subjects: Animals; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Applied microbiology; Bacillus megaterium - chemistry; Biological and medical sciences; Butyrates - chemistry; Butyrates - isolation & purification; Butyrates - pharmacology; Butyric Acid; Chemotherapic agents; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - isolation & purification; Enzyme Inhibitors - pharmacology; Fundamental and applied biological sciences. Psychology; Histocompatibility Antigens Class I - metabolism; Histone Deacetylase Inhibitors; Hydroxamic Acids - chemistry; Hydroxamic Acids - isolation & purification; Hydroxamic Acids - pharmacology; Melanoma, Experimental - immunology; Mice; Microbiology; Pentanoic Acids - chemistry; Pentanoic Acids - isolation & purification; Pentanoic Acids - pharmacology; Up-Regulation
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.51.89

In a previous report, we showed that anthracyclines up-regulate the cell surface expression of MHC class-I molecules in Bl6/BL6 cells. By using the same assay system, we found an other type of MHC class-I up-regulator in the culture broth of a newly isolated soil bacterium, Bacillus megaterium 6N38. Here we report the isolation and characterization of this up-regulator, and its possible molecular mechanism.