Characterization of the human gene coding for the swelling-dependent chloride channel ICln at position 11q13.5-14.1 (CLNS1A) and further characterization of the chromosome 6 (CLNS1B) localization

Expression cloning revealed a chloride channel (ICln) that we found to be fundamental for the regulatory volume decrease in a variety of cells. The chromosomal localization of the human ICln-gene showed two loci, one at chromosome 11 in position q13.5-q14.1, termed CLNS1A, and a second one at chromo...

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Bibliographic Details
Published in:Gene 1998-03, Vol.209 (1-2), p.59-63
Main Authors: Nagl, U O, Erdel, M, Bergmann, F, Oehl, B, Scandella, E, Musante, L, Galietta, L J, Gschwentner, M, Fürst, J, Schmarda, A, Hofer, S, Utermann, G, Deetjen, P, Paulmichl, M
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Base Sequence
Chloride Channels - biosynthesis
Chloride Channels - chemistry
Chloride Channels - genetics
Chromosome Mapping
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 6
DNA Primers
Exons
Genomic Library
Humans
In Situ Hybridization, Fluorescence
Introns
Ion Channels
Molecular Sequence Data
Open Reading Frames
Polymerase Chain Reaction
Sequence Alignment
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
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Summary:Expression cloning revealed a chloride channel (ICln) that we found to be fundamental for the regulatory volume decrease in a variety of cells. The chromosomal localization of the human ICln-gene showed two loci, one at chromosome 11 in position q13.5-q14.1, termed CLNS1A, and a second one at chromosome 6 at position p12.1-q13, termed CLNS1B. In this study, we offer a detailed characterization of the CLNS1A gene and provide the exact position (6p12) and sequence data of CLNS1B, an intronless gene 91.3% homologous to the coding region of CLNS1A.
ISSN:0378-1119
DOI:10.1016/S0378-1119(98)00002-X