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A 36-kDa mitochondrial protein is responsible for cyanide-resistant respiration in Hansenula anomala
Antimycin A-dependent induction of cyanide-resistant respiration in Hansenula anomala was reversibly blocked by carbonylcyanide- m-chlorophenylhydrazone (CCCP). When the cells were pulse-labeled with [ 35S]methionine in the presence of both antimycin A and CCCP, the radioactivity was incorporated in...
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| Published in: | FEBS letters 1990-05, Vol.264 (1), p.149-152 |
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| Main Authors: | , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c481J-1adb4980bb864f3dcc2d71c1d27a47ce0225ffd22740de030d5d7779b77661c03 |
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| container_start_page | 149 |
| container_title | FEBS letters |
| container_volume | 264 |
| creator | Minagawa, Nobuko Sakajo, Shigeru Komiyama, Tadazumi Yoshimoto, Akio |
| description | Antimycin A-dependent induction of cyanide-resistant respiration in
Hansenula anomala was reversibly blocked by carbonylcyanide-
m-chlorophenylhydrazone (CCCP). When the cells were pulse-labeled with [
35S]methionine in the presence of both antimycin A and CCCP, the radioactivity was incorporated into a 39 kDa mitochondrial protein. Upon removal of CCCP, this protein was processed into a 36 kDa form. The increase in the 36 kDa protein completely paralleled that in cyanide-resistant respiration activity, suggesting that the 39 kDa protein is the precursor of the 36 kDa protein, which is responsible for cyanide-resistant respiration. |
| doi_str_mv | 10.1016/0014-5793(90)80787-J |
| format | article |
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Hansenula anomala was reversibly blocked by carbonylcyanide-
m-chlorophenylhydrazone (CCCP). When the cells were pulse-labeled with [
35S]methionine in the presence of both antimycin A and CCCP, the radioactivity was incorporated into a 39 kDa mitochondrial protein. Upon removal of CCCP, this protein was processed into a 36 kDa form. The increase in the 36 kDa protein completely paralleled that in cyanide-resistant respiration activity, suggesting that the 39 kDa protein is the precursor of the 36 kDa protein, which is responsible for cyanide-resistant respiration.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(90)80787-J</identifier><identifier>PMID: 2338139</identifier><identifier>CODEN: FEBLAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Alternative oxidase ; Antimycin A - pharmacology ; Biological and medical sciences ; BSA, bovine serum albumin ; Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology ; CCCP, carbonylcyanide-m-chlorophenylhydrazone ; Cell structures and functions ; cyanide ; Cyanide-resistant respiration ; Fundamental and applied biological sciences. Psychology ; Fungal Proteins - biosynthesis ; Fungal Proteins - isolation & purification ; Fungal Proteins - metabolism ; Kinetics ; Methionine - metabolism ; Mitochondria ; Mitochondria - drug effects ; Mitochondria - metabolism ; Mitochondria and cell respiration ; Molecular and cellular biology ; Molecular Weight ; Nitriles - pharmacology ; oxidase ; Oxygen Consumption - drug effects ; Pichia - metabolism ; PMSF, phenylmethane sulfonylfluoride ; Precursor ; Protein import ; respiration ; Saccharomycetales - metabolism ; Spheroplasts - drug effects ; Spheroplasts - metabolism</subject><ispartof>FEBS letters, 1990-05, Vol.264 (1), p.149-152</ispartof><rights>1990</rights><rights>FEBS Letters 264 (1990) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481J-1adb4980bb864f3dcc2d71c1d27a47ce0225ffd22740de030d5d7779b77661c03</citedby><cites>FETCH-LOGICAL-c481J-1adb4980bb864f3dcc2d71c1d27a47ce0225ffd22740de030d5d7779b77661c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/001457939080787J$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3549,27924,27925,45780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19763225$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2338139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Minagawa, Nobuko</creatorcontrib><creatorcontrib>Sakajo, Shigeru</creatorcontrib><creatorcontrib>Komiyama, Tadazumi</creatorcontrib><creatorcontrib>Yoshimoto, Akio</creatorcontrib><title>A 36-kDa mitochondrial protein is responsible for cyanide-resistant respiration in Hansenula anomala</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Antimycin A-dependent induction of cyanide-resistant respiration in
Hansenula anomala was reversibly blocked by carbonylcyanide-
m-chlorophenylhydrazone (CCCP). When the cells were pulse-labeled with [
35S]methionine in the presence of both antimycin A and CCCP, the radioactivity was incorporated into a 39 kDa mitochondrial protein. Upon removal of CCCP, this protein was processed into a 36 kDa form. The increase in the 36 kDa protein completely paralleled that in cyanide-resistant respiration activity, suggesting that the 39 kDa protein is the precursor of the 36 kDa protein, which is responsible for cyanide-resistant respiration.</description><subject>Alternative oxidase</subject><subject>Antimycin A - pharmacology</subject><subject>Biological and medical sciences</subject><subject>BSA, bovine serum albumin</subject><subject>Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology</subject><subject>CCCP, carbonylcyanide-m-chlorophenylhydrazone</subject><subject>Cell structures and functions</subject><subject>cyanide</subject><subject>Cyanide-resistant respiration</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fungal Proteins - biosynthesis</subject><subject>Fungal Proteins - isolation & purification</subject><subject>Fungal Proteins - metabolism</subject><subject>Kinetics</subject><subject>Methionine - metabolism</subject><subject>Mitochondria</subject><subject>Mitochondria - drug effects</subject><subject>Mitochondria - metabolism</subject><subject>Mitochondria and cell respiration</subject><subject>Molecular and cellular biology</subject><subject>Molecular Weight</subject><subject>Nitriles - pharmacology</subject><subject>oxidase</subject><subject>Oxygen Consumption - drug effects</subject><subject>Pichia - metabolism</subject><subject>PMSF, phenylmethane sulfonylfluoride</subject><subject>Precursor</subject><subject>Protein import</subject><subject>respiration</subject><subject>Saccharomycetales - metabolism</subject><subject>Spheroplasts - drug effects</subject><subject>Spheroplasts - metabolism</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><recordid>eNqNUcGOFCEQJUazjqt_oAkXzXpohYZu4GKyrjuuk0286JnQUB1RGkbo0czfLz0zWW_qiVDv1atXrxB6TskbSmj_lhDKm04odqHIa0mEFM3mAVpRKVjDeC8fotU95TF6Usp3Uv-SqjN01jImKVMr5C4x65sfHwye_JzstxRd9ibgbU4z-Ih9wRnKNsXihwB4TBnbvYneQVPrvswmzgeGz2b2qTZEfGNigbgLBpuYJhPMU_RoNKHAs9N7jr6ur79c3TS3nz9-urq8bSyXdNNQ4wauJBkG2fOROWtbJ6ilrhWGCwukbbtxdG0rOHFAGHGdE0KoQYi-p5awc_TqqFvd_9xBmfXki4UQTIS0K1oo0UvSsX8SaddT3qlFkR-JNqdSMox6m_1k8l5Topcr6CVivUSsFdGHK-hNbXtx0t8NE7j7plPsFX95wk2xJozZROvLH-3qk9VlK2995P32Afb_NVuvr9-3C7DUFTlUF0PvjkJQ4__lIetiPUQLzmews3bJ_32jOxo-t0k</recordid><startdate>19900507</startdate><enddate>19900507</enddate><creator>Minagawa, Nobuko</creator><creator>Sakajo, Shigeru</creator><creator>Komiyama, Tadazumi</creator><creator>Yoshimoto, Akio</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>M81</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19900507</creationdate><title>A 36-kDa mitochondrial protein is responsible for cyanide-resistant respiration in Hansenula anomala</title><author>Minagawa, Nobuko ; Sakajo, Shigeru ; Komiyama, Tadazumi ; Yoshimoto, Akio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481J-1adb4980bb864f3dcc2d71c1d27a47ce0225ffd22740de030d5d7779b77661c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Alternative oxidase</topic><topic>Antimycin A - pharmacology</topic><topic>Biological and medical sciences</topic><topic>BSA, bovine serum albumin</topic><topic>Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology</topic><topic>CCCP, carbonylcyanide-m-chlorophenylhydrazone</topic><topic>Cell structures and functions</topic><topic>cyanide</topic><topic>Cyanide-resistant respiration</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fungal Proteins - biosynthesis</topic><topic>Fungal Proteins - isolation & purification</topic><topic>Fungal Proteins - metabolism</topic><topic>Kinetics</topic><topic>Methionine - metabolism</topic><topic>Mitochondria</topic><topic>Mitochondria - drug effects</topic><topic>Mitochondria - metabolism</topic><topic>Mitochondria and cell respiration</topic><topic>Molecular and cellular biology</topic><topic>Molecular Weight</topic><topic>Nitriles - pharmacology</topic><topic>oxidase</topic><topic>Oxygen Consumption - drug effects</topic><topic>Pichia - metabolism</topic><topic>PMSF, phenylmethane sulfonylfluoride</topic><topic>Precursor</topic><topic>Protein import</topic><topic>respiration</topic><topic>Saccharomycetales - metabolism</topic><topic>Spheroplasts - drug effects</topic><topic>Spheroplasts - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Minagawa, Nobuko</creatorcontrib><creatorcontrib>Sakajo, Shigeru</creatorcontrib><creatorcontrib>Komiyama, Tadazumi</creatorcontrib><creatorcontrib>Yoshimoto, Akio</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biochemistry Abstracts 3</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Minagawa, Nobuko</au><au>Sakajo, Shigeru</au><au>Komiyama, Tadazumi</au><au>Yoshimoto, Akio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A 36-kDa mitochondrial protein is responsible for cyanide-resistant respiration in Hansenula anomala</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1990-05-07</date><risdate>1990</risdate><volume>264</volume><issue>1</issue><spage>149</spage><epage>152</epage><pages>149-152</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>Antimycin A-dependent induction of cyanide-resistant respiration in
Hansenula anomala was reversibly blocked by carbonylcyanide-
m-chlorophenylhydrazone (CCCP). When the cells were pulse-labeled with [
35S]methionine in the presence of both antimycin A and CCCP, the radioactivity was incorporated into a 39 kDa mitochondrial protein. Upon removal of CCCP, this protein was processed into a 36 kDa form. The increase in the 36 kDa protein completely paralleled that in cyanide-resistant respiration activity, suggesting that the 39 kDa protein is the precursor of the 36 kDa protein, which is responsible for cyanide-resistant respiration.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2338139</pmid><doi>10.1016/0014-5793(90)80787-J</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | FEBS letters, 1990-05, Vol.264 (1), p.149-152 |
| issn | 0014-5793 1873-3468 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Alternative oxidase Antimycin A - pharmacology Biological and medical sciences BSA, bovine serum albumin Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology CCCP, carbonylcyanide-m-chlorophenylhydrazone Cell structures and functions cyanide Cyanide-resistant respiration Fundamental and applied biological sciences. Psychology Fungal Proteins - biosynthesis Fungal Proteins - isolation & purification Fungal Proteins - metabolism Kinetics Methionine - metabolism Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondria and cell respiration Molecular and cellular biology Molecular Weight Nitriles - pharmacology oxidase Oxygen Consumption - drug effects Pichia - metabolism PMSF, phenylmethane sulfonylfluoride Precursor Protein import respiration Saccharomycetales - metabolism Spheroplasts - drug effects Spheroplasts - metabolism |
| title | A 36-kDa mitochondrial protein is responsible for cyanide-resistant respiration in Hansenula anomala |
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