Effect of cimetidine and ranitidine on the hepatic and renal elimination of nicotine in humans

In a randomized, double-blind, cross-over experiment, 6 healthy consenting male subjects were administered cimetidine 600 mg or ranitidine 300 mg or placebo p.o. q12h x 2 days. Nicotine bitartrate was administered i.v. on day 2 (1 microgram/kg/min) x 30 min. After cimetidine mean nicotine total and...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1990-02, Vol.38 (2), p.165-169
Main Authors: BENDAYAN, R, SULLIVAN, J. T, SHAW, C, FRECKER, R. C, SELLERS, E. M
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cimetidine - pharmacology
Cotinine - pharmacokinetics
Double-Blind Method
Humans
Injections, Intravenous
Liver - drug effects
Liver - metabolism
Male
Medical sciences
Middle Aged
Nicotine - blood
Nicotine - pharmacokinetics
Nicotine - urine
Random Allocation
Ranitidine - pharmacology
Tobacco, tobacco smoking
Toxicology
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Summary:In a randomized, double-blind, cross-over experiment, 6 healthy consenting male subjects were administered cimetidine 600 mg or ranitidine 300 mg or placebo p.o. q12h x 2 days. Nicotine bitartrate was administered i.v. on day 2 (1 microgram/kg/min) x 30 min. After cimetidine mean nicotine total and metabolic clearances were decreased by 30% and 27% while after ranitidine the clearances were decreased by 10% and 7% respectively. Since smokers regulate their smoke intake based in large part on their nicotine blood levels these results suggest that the diminished nicotine total clearance in the presence of cimetidine could be important in assisting smoking reduction or cessation.
ISSN:0031-6970
1432-1041
DOI:10.1007/bf00265978