Central pressor effect of parathyroid hormone-related protein in conscious rats

Although the parathyroid hormone-related protein gene is widely expressed in the central nervous system, the role of this protein in blood pressure is unknown. This article examines whether parathyroid hormone-related protein is involved in the central regulation of blood pressure. An intraventricul...

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Bibliographic Details
Published in:Brain research 1998-02, Vol.785 (1), p.75-79
Main Authors: Nagao, Shoichi, Seto, Shinji, Kitamura, Shin-ichi, Akahoshi, Masazumi, Kiriyama, Takeshi, Yano, Katsusuke
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Antibodies, Monoclonal - pharmacology
Biological and medical sciences
Blood pressure
Blood Pressure - drug effects
Central nervous system
Cerebral Ventricles - drug effects
Cerebral Ventricles - physiology
Fundamental and applied biological sciences. Psychology
Ganglionic Blockers - pharmacology
Heart Rate - drug effects
Hemodynamics. Rheology
Hexamethonium - pharmacology
Injections, Intraventricular
Male
Monoclonal antibody
Parathyroid Hormone-Related Protein
Proteins - administration & dosage
Proteins - immunology
Proteins - pharmacology
Rats
Rats, Sprague-Dawley
Sympathetic nervous system
Time Factors
Vertebrates: cardiovascular system
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Summary:Although the parathyroid hormone-related protein gene is widely expressed in the central nervous system, the role of this protein in blood pressure is unknown. This article examines whether parathyroid hormone-related protein is involved in the central regulation of blood pressure. An intraventricularly injected solution of parathyroid hormone-related protein elicited a dose-dependent increase of mean arterial pressure accompanied by a decrease of heart rate in conscious Sprague–Dawley rats. An anti-parathyroid hormone-related protein monoclonal antibody, given in an intraventricularly injected solution, blocked the pressor effect of parathyroid hormone-related protein. Furthermore, this pressor effect of parathyroid hormone-related protein was also abolished after pretreatment by intravenous administration of either hexamethonium bromide or doxazosin mesylate. These results suggest that central parathyroid hormone-related protein is implicated in the regulation of blood pressure, and that this effect may be mediated through sympathetic activation.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(97)01385-1