A new heart failure model in rat by an end-to-side femoral vessel anastomosis

The aim of this study was to develop a new shunting procedure for producing heart failure in the rat incorporating microvascular techniques and avoiding an abdominal operation. We performed an end-to-side anastomosis between the femoral vein and the femoral artery just proximal to their trifurcation...

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Bibliographic Details
Published in:Cardiovascular research 1998, Vol.37 (1), p.236-238
Main Authors: OZEK, C, ZHANG, F, LINEAWEAVER, W. C, CHIN, B. T, EIMAN, T, NEWLIN, L, BUNCKE, H. J
Format: Article
Language:English
Subjects:
Anastomosis, Surgical
Animals
Biological and medical sciences
Cardiology. Vascular system
Disease Models, Animal
Femoral Artery - surgery
Femoral Vein - surgery
Heart
Heart Failure
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Medical sciences
Rats
Rats, Inbred Strains
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Summary:The aim of this study was to develop a new shunting procedure for producing heart failure in the rat incorporating microvascular techniques and avoiding an abdominal operation. We performed an end-to-side anastomosis between the femoral vein and the femoral artery just proximal to their trifurcation into the saphenous, epigastric, and distal femoral vessels. Of the 15 rats which underwent this procedure, six died within 48 h. The nine surviving animals were sacrificed and examined six weeks following surgery. All nine had developed cardiac hypertrophy and cardiac failure. This model provides a relatively simple and reproducible means of creating high output heart failure and cardiac hypertrophy in the rat without necessitating abdominal surgery.
ISSN:0008-6363
1755-3245
DOI:10.1016/S0008-6363(97)00219-8