Intra- and extracellular water dynamics on rehydration in cholera and noncholera patients

To estimate the intra- and extracellular body water compartments during rehydration of patients with cholera and noncholera diarrhea by bioimpedance analyzer, we studied 30 patients with acute watery diarrhea. Total body water (TBW), intracellular water (ICW), and extracellular water (ECW) of severe...

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Bibliographic Details
Published in:Digestive diseases and sciences 1998-03, Vol.43 (3), p.663-667
Main Authors: HOSSAIN, M. I, KABIR, I, FUCHS, G. J, MCCUTCHEON, M. J, ALVAREZ, J. O, KHALED, M. A
Format: Article
Language:English
Subjects:
Adult
Bacterial diseases
Biological and medical sciences
Body Composition
Body Water - physiology
Case-Control Studies
Cholera
Cholera - physiopathology
Cholera - therapy
Diarrhea - physiopathology
Diarrhea - therapy
Electric Impedance
Female
Fluid Therapy
Human bacterial diseases
Humans
Infectious diseases
Male
Medical sciences
Rehydration Solutions - therapeutic use
Time Factors
Tropical bacterial diseases
Tropical medicine
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Summary:To estimate the intra- and extracellular body water compartments during rehydration of patients with cholera and noncholera diarrhea by bioimpedance analyzer, we studied 30 patients with acute watery diarrhea. Total body water (TBW), intracellular water (ICW), and extracellular water (ECW) of severely dehydrated adult patients were measured with a dual frequency bioimpedance analyzer at different phases of rehydration. Fluid compartments between cholera and noncholera patients were compared. Cholera patients gained more TBW than noncholera patients during recovery. Unlike patients with noncholera diarrhea, the gain in cholera patients was mainly contributed by the ICW (1.5 +/- 1.6 vs 3.0 +/- 1.2 liters, respectively, P < 0.01). It was also observed that the recovery of the ICW compartment in cholera patients occurred rapidly within the first 2 hr after infusion. Differential dynamics of body water compartments in cholera compared to noncholera patients as observed in this study may contribute further to understanding the mechanism of dehydration in diarrheal disease, which might help in improving case management.
ISSN:0163-2116
1573-2568
DOI:10.1023/A:1018891914622