Estrogen receptor polymorphism at codon 325 and risk of breast cancer in women before age forty

The estrogen receptor (ER) protein is believed to play a role in the development and progression of breast cancer. In a previously published U.S. clinic-based study, a polymorphism in the ER gene (codon 325, CCC --> CCG) was found to be more common in 34 case subjects with a family history of bre...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1998-04, Vol.90 (7), p.532-536
Main Authors: SOUTHEY, M. C, BATTEN, L. E, MCCREDIE, M. R. E, GILES, G. G, DITE, G, HOPPER, J. L, VENTER, D. J
Format: Article
Language:English
Subjects:
Adult
Alleles
Australia
Biological and medical sciences
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Case-Control Studies
Codon - genetics
DNA Primers
Estrogens
Female
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical research
Medical sciences
Odds Ratio
Polymorphism, Genetic
Receptors, Estrogen - genetics
Tumors
Women
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Summary:The estrogen receptor (ER) protein is believed to play a role in the development and progression of breast cancer. In a previously published U.S. clinic-based study, a polymorphism in the ER gene (codon 325, CCC --> CCG) was found to be more common in 34 case subjects with a family history of breast cancer than in 154 case subjects without such a history (mean allele frequencies +/- standard error = 0.28+/-0.05 versus 0.11+/-0.02; P
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/90.7.532