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Increased heart rate in depressed subjects in spite of unchanged autonomic balance?
A clinical study was conducted to examine the effects of depression on cardiac autonomic control. Cardiac autonomic control was measured in 26 nonmedicated patients (19 females) suffering from Major Depression, melancholic type, and in 26 age- and sex-matched normal controls. We measured heart rate...
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| Published in: | Journal of affective disorders 1998-03, Vol.48 (2), p.115-124 |
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| Main Authors: | , , , , , , , , |
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| container_end_page | 124 |
| container_issue | 2 |
| container_start_page | 115 |
| container_title | Journal of affective disorders |
| container_volume | 48 |
| creator | Moser, Maximilian Lehofer, Michael Hoehn-Saric, Rudolf McLeod, Daniel R Hildebrandt, Gunther Steinbrenner, Birgit Voica, Magdalena Liebmann, Peter Zapotoczky, Hans-Georg |
| description | A clinical study was conducted to examine the effects of depression on cardiac autonomic control. Cardiac autonomic control was measured in 26 nonmedicated patients (19 females) suffering from Major Depression, melancholic type, and in 26 age- and sex-matched normal controls. We measured heart rate and high frequency heart rate variability (respiratory sinus arrhythmia), pulsewave velocity and blood pressure, during 10 min of supine rest under controlled conditions. Using a log transformed time domain measure of respiratory sinus arrhythmia (logRSA), we found an inverse linear dependence between cardiac vagal tone and age in the healthy subjects as well as the depressed patients. logRSA was 0.22±0.25 in the patients and 0.25±0.16 in the control group. While this difference was not significant (
P>0.1), the deviations from the regression line were significantly (
P |
| doi_str_mv | 10.1016/S0165-0327(97)00164-X |
| format | article |
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P>0.1), the deviations from the regression line were significantly (
P<0.0005) greater in the patients (0.21±0.12) than in the control group (0.09±0.07), indicating a more heterogenous vagal tone in the depressed patients. Heart rate was also significantly (
P<0.03) greater in the depressed patients (76.6±12.4) than in the control group (69.5±6.9). No between-group differences were found in pulsewave velocity or systolic blood pressure, but diastolic blood pressure was lower in depressed patients (73.5±8.7 vs. 80.8±9.1). We discuss the possibility that the increased heart rate seen in the absence of vagal tone changes may not be due to altered vagal or sympathetic tone, as measured in this study. Other factors, including altered autonomous heart rate, may be responsible for the higher heart rate in the depressed group.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/S0165-0327(97)00164-X</identifier><identifier>PMID: 9543200</identifier><identifier>CODEN: JADID7</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Adult and adolescent clinical studies ; Age ; Age Factors ; Autonomic Nervous System - physiopathology ; Autonomous heart rate ; Biological and medical sciences ; Blood pressure ; Cardiac vagal tone ; Case-Control Studies ; Depression ; Depressive Disorder - physiopathology ; Electrocardiography ; Female ; Heart Rate - physiology ; Humans ; Linear Models ; Major depression ; Male ; Medical sciences ; Middle Aged ; Mood disorders ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Pulse ; Pulse wave velocity ; Respiratory sinus arrhythmia</subject><ispartof>Journal of affective disorders, 1998-03, Vol.48 (2), p.115-124</ispartof><rights>1998 Elsevier Science B.V.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c554t-e6f7ccefee0272dc2e614c44043b213263dc46cf956da163a7c10386ed0125cc3</citedby><cites>FETCH-LOGICAL-c554t-e6f7ccefee0272dc2e614c44043b213263dc46cf956da163a7c10386ed0125cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2203818$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9543200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moser, Maximilian</creatorcontrib><creatorcontrib>Lehofer, Michael</creatorcontrib><creatorcontrib>Hoehn-Saric, Rudolf</creatorcontrib><creatorcontrib>McLeod, Daniel R</creatorcontrib><creatorcontrib>Hildebrandt, Gunther</creatorcontrib><creatorcontrib>Steinbrenner, Birgit</creatorcontrib><creatorcontrib>Voica, Magdalena</creatorcontrib><creatorcontrib>Liebmann, Peter</creatorcontrib><creatorcontrib>Zapotoczky, Hans-Georg</creatorcontrib><title>Increased heart rate in depressed subjects in spite of unchanged autonomic balance?</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>A clinical study was conducted to examine the effects of depression on cardiac autonomic control. Cardiac autonomic control was measured in 26 nonmedicated patients (19 females) suffering from Major Depression, melancholic type, and in 26 age- and sex-matched normal controls. We measured heart rate and high frequency heart rate variability (respiratory sinus arrhythmia), pulsewave velocity and blood pressure, during 10 min of supine rest under controlled conditions. Using a log transformed time domain measure of respiratory sinus arrhythmia (logRSA), we found an inverse linear dependence between cardiac vagal tone and age in the healthy subjects as well as the depressed patients. logRSA was 0.22±0.25 in the patients and 0.25±0.16 in the control group. While this difference was not significant (
P>0.1), the deviations from the regression line were significantly (
P<0.0005) greater in the patients (0.21±0.12) than in the control group (0.09±0.07), indicating a more heterogenous vagal tone in the depressed patients. Heart rate was also significantly (
P<0.03) greater in the depressed patients (76.6±12.4) than in the control group (69.5±6.9). No between-group differences were found in pulsewave velocity or systolic blood pressure, but diastolic blood pressure was lower in depressed patients (73.5±8.7 vs. 80.8±9.1). We discuss the possibility that the increased heart rate seen in the absence of vagal tone changes may not be due to altered vagal or sympathetic tone, as measured in this study. Other factors, including altered autonomous heart rate, may be responsible for the higher heart rate in the depressed group.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Age</subject><subject>Age Factors</subject><subject>Autonomic Nervous System - physiopathology</subject><subject>Autonomous heart rate</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Cardiac vagal tone</subject><subject>Case-Control Studies</subject><subject>Depression</subject><subject>Depressive Disorder - physiopathology</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Major depression</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Pulse</subject><subject>Pulse wave velocity</subject><subject>Respiratory sinus arrhythmia</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqFkMtKAzEUhoMotV4eoTALEV2M5jJJOiuR4qVQcKGCu5CenLEp7UxNZgTf3owt3bpJyPm_k5x8hIwYvWGUqdvXtMicCq6vSn1N06nIPw7IkEktci6ZPiTDPXJMTmJcUkpVqemADEpZCE7pkLxOawhoI7psgTa0WbAtZr7OHG4Cxr4eu_kSoY19NW58ipsq62pY2PozxbZrm7pZe8jmdmVrwLszclTZVcTz3X5K3h8f3ibP-ezlaTq5n-UgZdHmqCoNgBUi5Zo74KhYAUVBCzHnTHAlHBQKqlIqZ5kSVgOjYqzQUcYlgDgll9t7N6H56jC2Zu0j4CpNgU0XjS71mI-VTqDcghCaGANWZhP82oYfw6jpZZo_maY3ZUpt_mSaj9Q32j3Qzdfo9l07eym_2OU2gl1VIX3fxz3GeRqXjRN2t8Uwyfj2GEwEj8mU8yGJNa7x_wzyCxSKkPM</recordid><startdate>19980301</startdate><enddate>19980301</enddate><creator>Moser, Maximilian</creator><creator>Lehofer, Michael</creator><creator>Hoehn-Saric, Rudolf</creator><creator>McLeod, Daniel R</creator><creator>Hildebrandt, Gunther</creator><creator>Steinbrenner, Birgit</creator><creator>Voica, Magdalena</creator><creator>Liebmann, Peter</creator><creator>Zapotoczky, Hans-Georg</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980301</creationdate><title>Increased heart rate in depressed subjects in spite of unchanged autonomic balance?</title><author>Moser, Maximilian ; Lehofer, Michael ; Hoehn-Saric, Rudolf ; McLeod, Daniel R ; Hildebrandt, Gunther ; Steinbrenner, Birgit ; Voica, Magdalena ; Liebmann, Peter ; Zapotoczky, Hans-Georg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c554t-e6f7ccefee0272dc2e614c44043b213263dc46cf956da163a7c10386ed0125cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Age</topic><topic>Age Factors</topic><topic>Autonomic Nervous System - physiopathology</topic><topic>Autonomous heart rate</topic><topic>Biological and medical sciences</topic><topic>Blood pressure</topic><topic>Cardiac vagal tone</topic><topic>Case-Control Studies</topic><topic>Depression</topic><topic>Depressive Disorder - physiopathology</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Major depression</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Pulse</topic><topic>Pulse wave velocity</topic><topic>Respiratory sinus arrhythmia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moser, Maximilian</creatorcontrib><creatorcontrib>Lehofer, Michael</creatorcontrib><creatorcontrib>Hoehn-Saric, Rudolf</creatorcontrib><creatorcontrib>McLeod, Daniel R</creatorcontrib><creatorcontrib>Hildebrandt, Gunther</creatorcontrib><creatorcontrib>Steinbrenner, Birgit</creatorcontrib><creatorcontrib>Voica, Magdalena</creatorcontrib><creatorcontrib>Liebmann, Peter</creatorcontrib><creatorcontrib>Zapotoczky, Hans-Georg</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moser, Maximilian</au><au>Lehofer, Michael</au><au>Hoehn-Saric, Rudolf</au><au>McLeod, Daniel R</au><au>Hildebrandt, Gunther</au><au>Steinbrenner, Birgit</au><au>Voica, Magdalena</au><au>Liebmann, Peter</au><au>Zapotoczky, Hans-Georg</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased heart rate in depressed subjects in spite of unchanged autonomic balance?</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>1998-03-01</date><risdate>1998</risdate><volume>48</volume><issue>2</issue><spage>115</spage><epage>124</epage><pages>115-124</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><coden>JADID7</coden><abstract>A clinical study was conducted to examine the effects of depression on cardiac autonomic control. Cardiac autonomic control was measured in 26 nonmedicated patients (19 females) suffering from Major Depression, melancholic type, and in 26 age- and sex-matched normal controls. We measured heart rate and high frequency heart rate variability (respiratory sinus arrhythmia), pulsewave velocity and blood pressure, during 10 min of supine rest under controlled conditions. Using a log transformed time domain measure of respiratory sinus arrhythmia (logRSA), we found an inverse linear dependence between cardiac vagal tone and age in the healthy subjects as well as the depressed patients. logRSA was 0.22±0.25 in the patients and 0.25±0.16 in the control group. While this difference was not significant (
P>0.1), the deviations from the regression line were significantly (
P<0.0005) greater in the patients (0.21±0.12) than in the control group (0.09±0.07), indicating a more heterogenous vagal tone in the depressed patients. Heart rate was also significantly (
P<0.03) greater in the depressed patients (76.6±12.4) than in the control group (69.5±6.9). No between-group differences were found in pulsewave velocity or systolic blood pressure, but diastolic blood pressure was lower in depressed patients (73.5±8.7 vs. 80.8±9.1). We discuss the possibility that the increased heart rate seen in the absence of vagal tone changes may not be due to altered vagal or sympathetic tone, as measured in this study. Other factors, including altered autonomous heart rate, may be responsible for the higher heart rate in the depressed group.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>9543200</pmid><doi>10.1016/S0165-0327(97)00164-X</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-0327 |
| ispartof | Journal of affective disorders, 1998-03, Vol.48 (2), p.115-124 |
| issn | 0165-0327 1573-2517 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Adolescent Adult Adult and adolescent clinical studies Age Age Factors Autonomic Nervous System - physiopathology Autonomous heart rate Biological and medical sciences Blood pressure Cardiac vagal tone Case-Control Studies Depression Depressive Disorder - physiopathology Electrocardiography Female Heart Rate - physiology Humans Linear Models Major depression Male Medical sciences Middle Aged Mood disorders Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Pulse Pulse wave velocity Respiratory sinus arrhythmia |
| title | Increased heart rate in depressed subjects in spite of unchanged autonomic balance? |
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