Evidence for HSP70-like protein in the RBC membrane of the hereditarily anemic Belgrade laboratory (b/b) rat

We have demonstrated that in normal and b/b rat red blood cells (RBCs) hsp70-like protein (heat shock protein 70-like) is localized in the cytosol and it is exported via exosomes during in vivo reticulocytes maturation. As we have presumed, in the mutant (b/b) rat, hsp70-like protein transfers from...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 1998-01, Vol.178 (1-2), p.119-125
Main Authors: Zarić, J, Glisin, V, Popović, Z
Format: Article
Language:English
Subjects:
Anemia - genetics
Anemia - metabolism
Animals
Binding Sites
Electrophoresis, Polyacrylamide Gel
Erythrocyte Membrane - metabolism
Heat tolerance
Hot Temperature
HSP70 Heat-Shock Proteins - blood
Hypoxia
Isoelectric Point
Molecular Weight
Proteins
Rats
Rats, Mutant Strains
Rats, Wistar
S100 Proteins - blood
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Summary:We have demonstrated that in normal and b/b rat red blood cells (RBCs) hsp70-like protein (heat shock protein 70-like) is localized in the cytosol and it is exported via exosomes during in vivo reticulocytes maturation. As we have presumed, in the mutant (b/b) rat, hsp70-like protein transfers from cytosol to the RBC membrane. In the normal rat RBCs this happens when those cells are submitted to heat stress conditions. Our study indicates that the presence of hsp70-like protein in the b/b rat RBC plasma membrane is consistent with a primary defect and is not a consequence of life long stress, i.e. hypoxia.
ISSN:0300-8177
1573-4919
DOI:10.1023/A:1006877026611