New imidazole alkaloids and zinc complexes from the Micronesian sponge Leucetta cf. chagosensis

Four new imidazole alkaloids, 2-5, along with the known isonaamidine B (1) were isolated from a Pacific sponge, Leucetta cf. chagosensis, collected from Yap, Federated States of Micronesia. Among these, 4 and 5 are zinc complexes derived from isonaamidine B and isonaamidine D. The structures of the...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1998-03, Vol.61 (3), p.384-386
Main Authors: Fu, X, Schmitz, F.J, Tanner, R.S, Kelly-Borges, M
Format: Article
Language:English
Subjects:
ALCALOIDE
ALCALOIDES
ALKALOIDS
Alkaloids - analysis
Alkaloids - isolation & purification
Alkaloids - pharmacology
Animals
Anti-Bacterial Agents
Anti-Infective Agents - pharmacology
ANTIFUNGAL PROPERTIES
ASPERGILLUS NIGER
Biological and medical sciences
Carbohydrate Sequence
CHEMICAL COMPOSITION
CHEMICAL STRUCTURE
Chromatography, High Pressure Liquid
CINC
CLATHRINIDA
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
DERIVATIVES
EPONGE
ESPECTROMETRIA
ESPONJAS
ESTRUCTURA QUIMICA
General pharmacology
IMIDAZOLE
IMIDAZOLES
Imidazoles - analysis
Imidazoles - isolation & purification
Imidazoles - pharmacology
ISNAAMDINE D
ISONAAMIDINE B
ISONAAMINE B
LEUCETTIDAE
Magnetic Resonance Spectroscopy
Medical sciences
Microbial Sensitivity Tests
Micronesia
Molecular Sequence Data
PARAZOA
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Porifera - chemistry
PROPIEDADES ANTIMICOSICAS
PROPRIETE ANTIFONGIQUE
Pseudomonas aeruginosa - drug effects
Saccharomyces cerevisiae - drug effects
SPECTRAL ANALYSIS
SPECTROMETRIE
SPECTROMETRY
SPONGES
Staphylococcus aureus - drug effects
STRUCTURE CHIMIQUE
YAP
ZINC
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Four new imidazole alkaloids, 2-5, along with the known isonaamidine B (1) were isolated from a Pacific sponge, Leucetta cf. chagosensis, collected from Yap, Federated States of Micronesia. Among these, 4 and 5 are zinc complexes derived from isonaamidine B and isonaamidine D. The structures of the new compounds were elucidated from spectral data. Isonaamidine D (3) showed weakly antifungal activity against Aspergillus niger with MIC = 100 micrograms/mL.
ISSN:0163-3864
1520-6025
DOI:10.1021/np970453q