Spontaneous tibial artery thrombosis associated with varicella pneumonia and free protein S deficiency

Pneumonia is the most common serious complication of varicella infection in adults. A variety of thrombotic complications including purpura fulminans and disseminated intravascular coagulation have been reported in children with varicella but not in adults. Two men with varicella pneumonia who had p...

Full description

Saved in:
Bibliographic Details
Published in:Journal of vascular surgery 1998-03, Vol.27 (3), p.563-567
Main Authors: Peyton, Brian D., Cutler, Bruce S., Stewart, F.Marc
Format: Article
Language:English
Subjects:
Adult
Antibodies, Antiphospholipid - blood
Biological and medical sciences
Chickenpox - complications
Femoral Artery
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
Middle Aged
Plasminogen Activators - therapeutic use
Pneumonia, Viral - complications
Protein S Deficiency - blood
Protein S Deficiency - complications
Protein S Deficiency - immunology
Radiography
Thrombosis - diagnostic imaging
Thrombosis - drug therapy
Thrombosis - etiology
Tibial Arteries
Urokinase-Type Plasminogen Activator - therapeutic use
Viral diseases
Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pneumonia is the most common serious complication of varicella infection in adults. A variety of thrombotic complications including purpura fulminans and disseminated intravascular coagulation have been reported in children with varicella but not in adults. Two men with varicella pneumonia who had profound lower extremity ischemia caused by thrombosis of the profunda femoris and tibial arteries are reported. Both patients had free protein S deficiency and vascular thrombosis in association with varicella pneumonia without overt evidence of disseminated intravascular coagulation or purpura fulminans. Antiphospholipid immunoglobulin G and immunoglobulin M antibodies were present in one, whereas the other had evidence of the lupus anticoagulant. The proposed pathogenesis and management options including intraarterial thrombolytic therapy with urokinase and the need for long-term anticoagulation are discussed. (J Vasc Surg 1998;27:563-7.)
ISSN:0741-5214
1097-6809
DOI:10.1016/S0741-5214(98)70335-0