High Incidence of Urinary JC Virus Excretion in Nonimmunosuppressed Older Patients

Urine specimens from 120 patients attending urologic clinics were screened by blot hybridization for the presence of a polyomavirus DNA. Detected viral DNA was then identified as BK or JC by fine restriction enzyme analysis. BK and JC viral DNA was found in 5 (4%) and 35 (29%) patients, respectively...

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Bibliographic Details
Published in:The Journal of infectious diseases 1990-06, Vol.161 (6), p.1128-1133
Main Authors: Kitamura, Tadaichi, Aso, Yoshio, Kuniyoshi, Noboru, Hara, Kazuya, Yogo, Yoshiaki
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Age groups
Aged
Aged, 80 and over
Autoradiography
Biological and medical sciences
BK virus
BK Virus - genetics
BK Virus - isolation & purification
Child
Child, Preschool
DNA Probes
DNA, Viral - urine
Electrophoresis, Agar Gel
Excretion
Female
Humans
Incidence
Infant
Infectious diseases
JC virus
JC Virus - genetics
JC Virus - isolation & purification
Major Articles
Male
Medical sciences
Middle Aged
Nucleic Acid Hybridization
Polyomavirus
Polyomavirus - isolation & purification
Recurrence
Restriction Mapping
Specimens
Tumor Virus Infections - epidemiology
Tumor Virus Infections - urine
Urine
Urine - microbiology
Viral diseases
Viral DNA
Viruses
Citations: Items that cite this one
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Description
Summary:Urine specimens from 120 patients attending urologic clinics were screened by blot hybridization for the presence of a polyomavirus DNA. Detected viral DNA was then identified as BK or JC by fine restriction enzyme analysis. BK and JC viral DNA was found in 5 (4%) and 35 (29%) patients, respectively. Detection rates were compared among three age groups: 0–29, 30–59, and 60–89 years. Detection of JC viral DNA increased with age and reached the highest value (45%) in the group aged 60–89 years. For BK viral DNA a correlation between detection and age was not clear because the rate of detection was low, although the highest rate (9%) occurred in the oldest group. To confirm the active urinary excretion of polyomavirus DNA in older patients, urine specimens from 23 patients (60–90 years) treated at an internal medicine clinic were examined for viral DNA. Bk and JC viral DNA were in 2 (9%) and 12 patients (52%), respectively. These results suggest that JC virus is frequently reactivated in older individuals.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/161.6.1128