Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes Off

The immune system responds in a regulated fashion to microbes and eliminates them, but it does not respond to self-antigens. Several regulatory mechanisms function to terminate responses to foreign antigens, returning the immune system to a basal state after the antigen has been cleared, and to main...

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Published in:Science (American Association for the Advancement of Science) 1998-04, Vol.280 (5361), p.243-248
Main Authors: Van Parijs, Luk, Abbas, Abul K.
Format: Article
Language:English
Subjects:
Animals
Antigens
Antigens - immunology
Apoptosis
Autoantigens
Autoantigens - immunology
Autoimmune Diseases - immunology
Autoimmune Diseases - prevention & control
B lymphocytes
B-Lymphocytes - cytology
B-Lymphocytes - immunology
Cellular biology
Clonal Anergy
Cytokines
Feedback (Response)
Homeostasis
Humans
Immune system
Individualized Instruction
Lymphocyte Activation
Lymphocytes
Memory
Mice
Observations
Receptors
Self Tolerance
Stimuli
T lymphocytes
T-Lymphocytes - cytology
T-Lymphocytes - immunology
Turning the Immune System Off
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description The immune system responds in a regulated fashion to microbes and eliminates them, but it does not respond to self-antigens. Several regulatory mechanisms function to terminate responses to foreign antigens, returning the immune system to a basal state after the antigen has been cleared, and to maintain unresponsiveness, or tolerance, to self-antigens. Here, recent advances in understanding of the molecular bases and physiologic roles of the mechanisms of immune homeostasis are examined.
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subjects Animals
Antigens
Antigens - immunology
Apoptosis
Autoantigens
Autoantigens - immunology
Autoimmune Diseases - immunology
Autoimmune Diseases - prevention & control
B lymphocytes
B-Lymphocytes - cytology
B-Lymphocytes - immunology
Cellular biology
Clonal Anergy
Cytokines
Feedback (Response)
Homeostasis
Humans
Immune system
Individualized Instruction
Lymphocyte Activation
Lymphocytes
Memory
Mice
Observations
Receptors
Self Tolerance
Stimuli
T lymphocytes
T-Lymphocytes - cytology
T-Lymphocytes - immunology
Turning the Immune System Off
title Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes Off
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