THERAPEUTIC EFFECTS OF CEFPIROME, A NEW CEPHALOSPORIN, ON VARIOUS MODELS OF INFECTIONS IN MICE AND RATS

• Published in: Japanese journal of antibiotics 1990/01/25, Vol.43(1), pp.1-8
• Main Authors: ARAI, SUSUMU, KOBAYASHI, SHINZO, HAYASHI, SHORYO
• Format: Article
• Language: English
• Subjects: Animals; Cefpirome; Cephalosporins - therapeutic use; Escherichia coli - drug effects; Female; Klebsiella Infections - drug therapy; Klebsiella pneumoniae; Lung Diseases - drug therapy; Male; Methicillin - pharmacology; Mice; Penicillin Resistance; Pseudomonas Infections - drug therapy; Pyelonephritis - drug therapy; Rats; Staphylococcal Infections - drug therapy; Staphylococcal Infections - microbiology; Staphylococcus aureus - drug effects; Uterine Diseases - drug therapy
• ISSN: 0368-2781; 2186-5477
• DOI: 10.11553/antibiotics1968b.43.1

Cefpirome (HR 810) is a new cephalosporin with a 2, 3-cyclopentenopyridine group in the 3-position side chain. It was compared with other cephem antibiotics in protective and therapeutic effects on various experimental infections, systemic and local, in mice and rats. HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced byEscherichia coliEc-31,Staphylococcus aureusSMITH, andSerratia marcescensSm-6 in mice. Against systemic infection withPseu-domonas aeruginosaHR 810 was as effective as CAZ. Mice with leukopenia induced by cyclophosphamide were systemically infected with methicillin-resistantS. aureus(MRSA), methicillin-susceptibleS. aureus(MSSA),Enterobacter cloacae, Acinetobacter calcoaceticus, andEnterococcus faecalis. HR 810 was superior to cefuzonam (CZON) and cefmetazole against MRSA and MSSA and was much more active than any other antibiotics tested againstE. cloacae and A. calcoaceticus. In the activity againstE. faecalis, HR 810 was inferior to ampicillin but superior to CZON. In mice with pyelonephritis caused byE. coliEc-7, the rank order of activities was HR 810> CAZ> CTX> CPZ. HR 810 was more effective than latamoxef, CAZ, CTX, and CPZ in improving lung infections induced byStreptococcus pneumoniaeHL 438 and Klebsiella pneumoniaeKp-51 in mice. HR 810 was superior to CTX and CPZ and comparable to cefazolin in therapeutic effects on intrauterine infections withE. coliEc-89 andS. aureusSMITH in rats.