Hematological indices in an older population sample: derivation of healthy reference values

Factors affecting hematological values were explored, and healthy reference values were estimated from a cross-sectional survey of a population (n = 4433), ages 49 years or more, residing permanently in a defined geographic region. Nursing home residents were excluded. Details of medication use and...

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Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Md.), 1998-01, Vol.44 (1), p.96-101
Main Authors: Tsang, Chiu Wah, Lazarus, Ross, Smith, Wayne, Mitchell, Paul, Koutts, Jerry, Burnett, Leslie
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Australia
Biological and medical sciences
Blood Cell Count
Creatinine - blood
Cross-Sectional Studies
Data Interpretation, Statistical
Erythrocyte Indices
Female
Hematocrit
Hematologic Tests - standards
Hemoglobins - analysis
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Miscellaneous. Technology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Reference Values
Sex Factors
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Summary:Factors affecting hematological values were explored, and healthy reference values were estimated from a cross-sectional survey of a population (n = 4433), ages 49 years or more, residing permanently in a defined geographic region. Nursing home residents were excluded. Details of medication use and medical history were obtained by interview, and participants were asked to return after an overnight fast for blood sampling. The participation rate was 82.4%, of whom 88.4% provided a fasting blood sample. Hemoglobin, hematocrit, and erythrocyte counts were higher in men, whereas platelet counts were higher in women. Statistical associations between each hematological index and smoking, alcohol intake, use of certain drugs, chronic disease, and high creatinine values were tested by unpaired t-tests. Separate reference groups were defined for each hematological index by excluding subjects with any of the factors found to be of importance. The resulting reference values are particularly appropriate for evaluating hematological test results in older individuals.
ISSN:0009-9147
1530-8561