Measurement of soluble transferrin receptor in serum of healthy adults

The concentration of soluble transferrin receptor (sTfR) in serum is reported to be useful in the diagnosis of iron deficiency, especially for patients with concurrent chronic disease, where routine tests of iron status are compromised by the inflammatory condition. A new diagnostic assay for sTfR i...

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Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Md.), 1998, Vol.44 (1), p.35-39
Main Authors: ALLEN, J, BACKSTROM, K. R, ROITMAN-JOHNSON, B, SELIGMAN, P. A, COOPER, J. A, COOPER, M. C, DETWILER, T. C, ESSEX, D. W, FRITZ, R. P, MEANS, R. T, MEIER, P. B, PEARLMAN, S. R
Format: Article
Language:English
Subjects:
Age Factors
Altitude
Biological and medical sciences
Continental Population Groups
Enzyme-Linked Immunosorbent Assay
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Metabolic diseases
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Postmenopause - blood
Premenopause - blood
Receptors, Transferrin - blood
Reference Values
Sensitivity and Specificity
Sex Factors
Solubility
United States
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Summary:The concentration of soluble transferrin receptor (sTfR) in serum is reported to be useful in the diagnosis of iron deficiency, especially for patients with concurrent chronic disease, where routine tests of iron status are compromised by the inflammatory condition. A new diagnostic assay for sTfR is calibrated against natural plasma sTfR, thus minimizing calibration discrepancies that result from differences between the analyte and the cellular transferrin receptor used in other assays. Use of the new assay to measure sTfR concentrations in 225 healthy, hematologically normal adults provided a reference interval against which pathological samples could be compared. There was no difference in the reference intervals for men and women and no correlation of [sTfR] with the age of the subject. Black subjects had significantly higher concentrations than nonblacks, and people living at high altitude had higher concentrations than those living closer to sea level. These differences were additive.
ISSN:0009-9147
1530-8561
DOI:10.1093/clinchem/44.1.35